دورية أكاديمية
Macrophages-mediated delivery of protoporphyrin for sonodynamic therapy of rheumatoid arthritis
| العنوان: | Macrophages-mediated delivery of protoporphyrin for sonodynamic therapy of rheumatoid arthritis |
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| المؤلفون: | Lin Wu, Kai Zhao, Leyuan Xu, Junming Cui, Li Ruan, Shifang Bei, Jin Cao, Xueyong Qi, Song Shen |
| المصدر: | Ultrasonics Sonochemistry, Vol 107, Iss , Pp 106928- (2024) |
| بيانات النشر: | Elsevier, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Chemistry LCC:Acoustics. Sound |
| مصطلحات موضوعية: | Iron oxide nanoparticles, Targeting delivery, Macrophages, Sonodynamic therapy, Rheumatoid arthritis, Chemistry, QD1-999, Acoustics. Sound, QC221-246 |
| الوصف: | Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease characterized by infiltration of inflammatory cells, hyperplasia of synovium, and destruction of the joint cartilage. Owing to the low drug delivery efficiency and limited immunosuppression effect, complete cure for RA remains a formidable challenge. Here, we show that live macrophages (Mφs) carrying protoporphyrin-loaded Fe3O4 nanoparticles can migrate to the RA tissues and inhibit the inflammation by sonodynamic therapy. The inflammation of RA leads to the release of cytokines, which guides the migration of the Mφs into the RA tissues, realizing precise delivery of therapeutics. The following sonodynamic therapy induced by ultrasound and protoporphyrin destructs the proliferating synovial cells and also infiltrated inflammatory cells, demonstrating significant therapeutic effect for RA. Meanwhile, the cytokines and relapse of RA can be remarkably suppressed because of the efficient damage to the resident inflammatory cells. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1350-4177 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S1350417724001767; https://doaj.org/toc/1350-4177 |
| DOI: | 10.1016/j.ultsonch.2024.106928 |
| URL الوصول: | https://doaj.org/article/f9042f49a3b7434f977a4a3e6c8d76e9 |
| رقم الأكسشن: | edsdoj.f9042f49a3b7434f977a4a3e6c8d76e9 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 13504177 |
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| DOI: | 10.1016/j.ultsonch.2024.106928 |