دورية أكاديمية
Biological roles and potential clinical values of circular RNAs in gastrointestinal malignancies
| العنوان: | Biological roles and potential clinical values of circular RNAs in gastrointestinal malignancies |
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| المؤلفون: | Xueping Tao, Yongfu Shao, Jianing Yan, Liyang Yang, Qihua Ye, Qingling Wang, Rongdan Lu, Junming Guo |
| المصدر: | Cancer Biology & Medicine, Vol 18, Iss 2, Pp 437-457 (2021) |
| بيانات النشر: | China Anti-Cancer Association, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | circular rna, gastrointestinal malignancies, biological function, clinical value, digestive system, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Circular RNAs (circRNAs), a class of endogenous RNA molecules, are produced by alternative splicing of precursor RNA and are covalently linked at the 5′ and 3′ ends. Recent studies have revealed that dysregulated circRNAs are closely related to the occurrence and progression of gastrointestinal malignancies. Accumulating evidence indicates that circRNAs, including circPVT1, circLARP4, circ-SFMBT2, cir-ITCH, circRNA_100782, circ_100395, circ-DONSON, hsa_circ_0001368, circNRIP1, circFAT1(e2), circCCDC66, circSMARCA5, circ-ZNF652, and circ_0030235 play important roles in the proliferation, differentiation, invasion, and metastasis of cancer cells through a variety of mechanisms, such as acting as microRNA sponges, interacting with RNA-binding proteins, regulating gene transcription and alternative splicing, and being translated into proteins. With the characteristics of high abundance, high stability, extensive functions, and certain tissue-, time- and disease-specific expressions, circRNAs are expected to provide novel perspectives for the diagnoses and treatments of gastrointestinal malignancies. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2095-3941 |
| Relation: | http://www.cancerbiomed.org/index.php/cocr/article/view/1817; https://doaj.org/toc/2095-3941 |
| DOI: | 10.20892/j.issn.2095-3941.2020.0348 |
| URL الوصول: | https://doaj.org/article/f91f536c3a1248b5bd12d78542892eed |
| رقم الأكسشن: | edsdoj.f91f536c3a1248b5bd12d78542892eed |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20953941 |
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| DOI: | 10.20892/j.issn.2095-3941.2020.0348 |