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Expression and Clinical Significance of Heparanase and Ki-67 in Non-small Cell Lung Cancer

التفاصيل البيبلوغرافية
العنوان: Expression and Clinical Significance of Heparanase and Ki-67 in Non-small Cell Lung Cancer
المؤلفون: Xiaoming QIU, Honglin ZHAO, Xin LI, Yi LIU, Jun CHEN, Sen WEI, Xiaohong XU, Zuoqing SONG, Naikang ZHOU
المصدر: Chinese Journal of Lung Cancer, Vol 12, Iss 7, Pp 785-788 (2009)
بيانات النشر: Chinese Anti-Cancer Association; Chinese Antituberculosis Association, 2009.
سنة النشر: 2009
المجموعة: LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
مصطلحات موضوعية: Lung neoplasms, Heparanase, Ki-67, Immunohistochemistry, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
الوصف: Background and objective It has been proven that heparanase and Ki-67 had relationship with occurrence and metastasis in lung cancer. The aim of this work was to investigate the expressions of heparanase and Ki-67 and to explore their clinical significance and mutual relations in non-small cell lung cancer (NSCLC). Methods Immunohistochemical method was used to detect the heparanase and Ki-67expression in the routinely paraffin-embedded sections of surgical specimen of 70 cases with NSCLC and 20 ones with normal lung tissues. Results Heparanase and Ki-67 were highly expressed in lung cancer tissues (72.9% and 85.7%) while negative in epithelia of normal lung tissues. The expression of heparanase was significantly correlated with TNM stage (P=0.044) and lymphatic metastasis (P=0.001). The expression of Ki-67 was significantly correlated with tumor size (P=0.03) and histology type (P=0.001) and differentiation (P=0.01) and lymphatic metastasis (P=0.01) and TNM stage (P=0.043). The expression of heparanase and Ki-67 was no significant difference (P=0.323). Conclusion Heparanase and Ki-67 were involved in the occurrence and development of lung cancer and they may predict patients prognosis, while the expression of heparanase and Ki-67 had no association with NSCLC, which may contribute to the different mechanisms involved in tumor occurrence and development.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: Chinese
تدمد: 1009-3419
1999-6187
Relation: http://www.lungca.org/index.php?journal=01&page=article&op=viewFile&path[]=10.3779%2Fj.issn.1009-3419.2009.07.008&path[]=948; https://doaj.org/toc/1009-3419; https://doaj.org/toc/1999-6187
URL الوصول: https://doaj.org/article/f94eb67897e2448997ba39017134228f
رقم الأكسشن: edsdoj.f94eb67897e2448997ba39017134228f
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:10093419
19996187