دورية أكاديمية
The past and present of paraoxonase enzyme: Its role in the cardiovascular system and some diseases
| العنوان: | The past and present of paraoxonase enzyme: Its role in the cardiovascular system and some diseases |
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| المؤلفون: | Aydin Suleyman, Sahin İbrahim, Aydin Suna, Aksoy Aziz, Citil Cihan |
| المصدر: | Journal of Medical Biochemistry, Vol 31, Iss 3, Pp 161-173 (2012) |
| بيانات النشر: | Society of Medical Biochemists of Serbia, Belgrade, 2012. |
| سنة النشر: | 2012 |
| المجموعة: | LCC:Biochemistry |
| مصطلحات موضوعية: | paraoxonase, polymorphism, cardiovascular system diseases, Biochemistry, QD415-436 |
| الوصف: | Although paraoxonase is synthesized in many tissues including the heart, colon, kidneys, lungs, small intestines and brain, its major locus of synthesis is the liver. PON1 is in close association with apolipoproteins and protects LDL against oxidation. It was reported that PON1 quantities dropped to 40 times lower than normal in cardiovascular diseases and diseases like diabetes, ulcerative colitis, Crohn's disease, chronic renal failure, SLE, Behcet's disease, cancer, hepatitis B, obesity, metabolic syndrome, Alzheimer's and dementia. It is speculated that the concerning decline in serum PON1 amount results from single nucleotide polymorphism in the coding (Q192R, L55M) and promoter (T-108C) sites of the PON1 gene. Additionally, circulating amounts of PON1 are affected by vitamins, antioxidants, fatty acids, dietary factors, drugs, age and lifestyle. This collection attempts to review and examine the past and present studies of paraoxonase and its relation with the cardiovascular system and some relevant diseases. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1452-8258 1452-8266 |
| Relation: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2012/1452-82581203161A.pdf; https://doaj.org/toc/1452-8258; https://doaj.org/toc/1452-8266 |
| URL الوصول: | https://doaj.org/article/f951e5d7d79147cfb2020bf11d1b931f |
| رقم الأكسشن: | edsdoj.f951e5d7d79147cfb2020bf11d1b931f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14528258 14528266 |
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