دورية أكاديمية
Neurophysiological mechanisms of cancer-induced bone pain
| العنوان: | Neurophysiological mechanisms of cancer-induced bone pain |
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| المؤلفون: | Xuan-Qi Zheng, Yu-hao Wu, Jin-feng Huang, Ai-Min Wu |
| المصدر: | Journal of Advanced Research, Vol 35, Iss , Pp 117-127 (2022) |
| بيانات النشر: | Elsevier, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine (General) LCC:Science (General) |
| مصطلحات موضوعية: | Cancer-induced bone pain, Central sensitization, Neuroinflammation, Acidic environment, TRPV, P2X Family, Medicine (General), R5-920, Science (General), Q1-390 |
| الوصف: | Background: Cancer-induced Bone Pain (CIBP) is an important factor affecting their quality of life of cancer survivors. In addition, current clinical practice and scientific research suggest that neuropathic pain is a representative component of CIBP. However, given the variability of cancer conditions and the complexity of neuropathic pain, related mechanisms have been continuously supplemented but have not been perfected. Aim of Review: Therefore, the current review highlights the latest progress in basic research on the field and proposes potential therapeutic targets, representative drugs and upcoming therapies. Key Scientific Concepts of Review: Notably, factors such as central sensitization, neuroinflammation, glial cell activation and an acidic environment are considered to be related to neuropathic pain in CIBP. Nonetheless, further research is needed to ascertain the mechanism of CIBP in order to develop highly effective drugs. Moreover, more attention needs to be paid to the care of patients with advanced cancer. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2090-1232 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2090123221001028; https://doaj.org/toc/2090-1232 |
| DOI: | 10.1016/j.jare.2021.06.006 |
| URL الوصول: | https://doaj.org/article/cf95df803cba42efb0a2438d1d242940 |
| رقم الأكسشن: | edsdoj.f95df803cba42efb0a2438d1d242940 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20901232 |
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| DOI: | 10.1016/j.jare.2021.06.006 |