دورية أكاديمية
miR‐33 in cardiometabolic diseases: lessons learned from novel animal models and approaches
| العنوان: | miR‐33 in cardiometabolic diseases: lessons learned from novel animal models and approaches |
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| المؤلفون: | Nathan L Price, Leigh Goedeke, Yajaira Suárez, Carlos Fernández‐Hernando |
| المصدر: | EMBO Molecular Medicine, Vol 13, Iss 5, Pp n/a-n/a (2021) |
| بيانات النشر: | Springer Nature, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine (General) LCC:Genetics |
| مصطلحات موضوعية: | atherosclerosis, metabolism, miR‐33, miRNA, Medicine (General), R5-920, Genetics, QH426-470 |
| الوصف: | Abstract miRNAs have emerged as critical regulators of nearly all biologic processes and important therapeutic targets for numerous diseases. However, despite the tremendous progress that has been made in this field, many misconceptions remain among much of the broader scientific community about the manner in which miRNAs function. In this review, we focus on miR‐33, one of the most extensively studied miRNAs, as an example, to highlight many of the advances that have been made in the miRNA field and the hurdles that must be cleared to promote the development of miRNA‐based therapies. We discuss how the generation of novel animal models and newly developed experimental techniques helped to elucidate the specialized roles of miR‐33 within different tissues and begin to define the specific mechanisms by which miR‐33 contributes to cardiometabolic diseases including obesity and atherosclerosis. This review will summarize what is known about miR‐33 and highlight common obstacles in the miRNA field and then describe recent advances and approaches that have allowed researchers to provide a more complete picture of the specific functions of this miRNA. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1757-4684 1757-4676 |
| Relation: | https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684 |
| DOI: | 10.15252/emmm.202012606 |
| URL الوصول: | https://doaj.org/article/f9de2e4064ff4f6b9075aa00a4d61d3c |
| رقم الأكسشن: | edsdoj.f9de2e4064ff4f6b9075aa00a4d61d3c |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17574684 17574676 |
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| DOI: | 10.15252/emmm.202012606 |