دورية أكاديمية
The Role of Sirtuin-1 (SIRT1) in the Physiology and Pathophysiology of the Human Placenta
| العنوان: | The Role of Sirtuin-1 (SIRT1) in the Physiology and Pathophysiology of the Human Placenta |
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| المؤلفون: | Mateusz Wątroba, Grzegorz Szewczyk, Dariusz Szukiewicz |
| المصدر: | International Journal of Molecular Sciences, Vol 24, Iss 22, p 16210 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | sirtuin-1, SIRT1, sirtuins, human placenta, placental physiology, placental pathophysiology, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Sirtuins, especially SIRT1, play a significant role in regulating inflammatory response, autophagy, and cell response to oxidative stress. Since their discovery, sirtuins have been regarded as anti-ageing and longevity-promoting enzymes. Sirtuin-regulated processes seem to participate in the most prevalent placental pathologies, such as pre-eclampsia. Furthermore, more and more research studies indicate that SIRT1 may prevent pre-eclampsia development or at least alleviate its manifestations. Having considered this, we reviewed recent studies on the role of sirtuins, especially SIRT1, in processes determining normal or abnormal development and functioning of the placenta. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/24/22/16210; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms242216210 |
| URL الوصول: | https://doaj.org/article/fa4d13c6b96747baa4bccca2a3eeec3a |
| رقم الأكسشن: | edsdoj.fa4d13c6b96747baa4bccca2a3eeec3a |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms242216210 |