دورية أكاديمية
Ontogenesis of the molecular response to sleep loss
| العنوان: | Ontogenesis of the molecular response to sleep loss |
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| المؤلفون: | Christine M. Muheim, Kaitlyn Ford, Elizabeth Medina, Kristan Singletary, Lucia Peixoto, Marcos G. Frank |
| المصدر: | Neurobiology of Sleep and Circadian Rhythms, Vol 14, Iss , Pp 100092- (2023) |
| بيانات النشر: | Elsevier, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Neurosciences. Biological psychiatry. Neuropsychiatry LCC:Biology (General) |
| مصطلحات موضوعية: | RNA, Gene, Molecular, Sleep deprivation, Postnatal, Sleep regulation, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Biology (General), QH301-705.5 |
| الوصف: | Sleep deprivation (SD) results in profound cellular and molecular changes in the adult mammalian brain. Some of these changes may result in, or aggravate, brain disease. However, little is known about how SD impacts gene expression in developing animals. We examined the transcriptional response in the prefrontal cortex (PFC) to SD across postnatal development in male mice. We used RNA sequencing to identify functional gene categories that were specifically impacted by SD. We find that SD has dramatically different effects on PFC genes depending on developmental age. Gene expression differences after SD fall into 3 categories: present at all ages (conserved), present when mature sleep homeostasis is first emerging, and those unique to certain ages. Developmentally conserved gene expression was limited to a few functional categories, including Wnt-signaling which suggests that this pathway is a core mechanism regulated by sleep. In younger ages, genes primarily related to growth and development are affected while changes in genes related to metabolism are specific to the effect of SD in adults. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2451-9944 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2451994423000044; https://doaj.org/toc/2451-9944 |
| DOI: | 10.1016/j.nbscr.2023.100092 |
| URL الوصول: | https://doaj.org/article/fa589c7d670e481192a0ed15cac33a92 |
| رقم الأكسشن: | edsdoj.fa589c7d670e481192a0ed15cac33a92 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24519944 |
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| DOI: | 10.1016/j.nbscr.2023.100092 |