دورية أكاديمية
Non-High-Density lipoprotein cholesterol or Apolipoprotein B in the prediction of myocardial infarction
| العنوان: | Non-High-Density lipoprotein cholesterol or Apolipoprotein B in the prediction of myocardial infarction |
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| المؤلفون: | Amit Kumar Pradhan, Ritabrata Mitra, Subinay Datta, Mrinal Pal |
| المصدر: | Al Ameen Journal of Medical Sciences, Vol 10, Iss 02, Pp 89-94 (2017) |
| بيانات النشر: | Al Ameen Medical College, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Therapeutics. Pharmacology LCC:Toxicology. Poisons |
| مصطلحات موضوعية: | ApoB, Low Density Lipoprotein cholesterol, Myocardial infarction, Non-High Density Lipoprotein, Therapeutics. Pharmacology, RM1-950, Toxicology. Poisons, RA1190-1270 |
| الوصف: | Background: It is well documented that elevated Low Density Lipoprotein cholesterol (LDL-C) is one of cardiovascular risk. However, not all patients of coronary heart disease possess elevated LDL-C level. There is a growing evidences that non-high density lipoprotein (non-HDL) cholesterol and Apo B carry on all of the potentially proatherogenic lipoproteins apart from LDL-C. The study was conducted to search the role of non-HDL(C) and ApoB as alternative to LDL-C for the better and useful predictor of myocardial infarction (MI). Methods: In this cross-sectional study, hundred patients of MI and 100 controls of age and sex matched were studied for LDL-C, non-HDL(C) and Apo B between March 2014 and April 2015 in the Department Cardiology and Biochemistry. Result: The data was analyzed using SPSS 11.5. Serum concentration of both non-HDL cholesterol and ApoB in cases is significantly higher than controls but no significant differences in concentration of serum LDL-C (Student’s t test). On regression analysis it was shown that serum non-HDLC is better correlated with apo B than is LDL-C. On ROC curve analysis, it was found that non-HDL(C) had both the sensitivity and the negative predictive value 100% and 95.1%, whereas specificity and positive predictive value of Apo B were 96% and 94.6% respectively. On the other hand sensitivity and negative predictive value were 100% and 96.3%, whereas specificity and positive predictive value were 95% and 95.7% respectively. Conclusion: Both apoB and non–HDL-C was better predictor of MI than LDL-C and among these two, non-HDL(C) is much better. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0974-1143 |
| Relation: | http://ajms.alameenmedical.org/ArticlePDFs/3%20AJMS%20V10.N2.2017%20p%2089-94.pdf; https://doaj.org/toc/0974-1143 |
| URL الوصول: | https://doaj.org/article/fac93227ff0043c194421084f1f845cd |
| رقم الأكسشن: | edsdoj.fac93227ff0043c194421084f1f845cd |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 09741143 |
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