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Clinical efficacy of tumor antigen-pulsed DC treatment for high-grade glioma patients: evidence from a meta-analysis.

التفاصيل البيبلوغرافية
العنوان: Clinical efficacy of tumor antigen-pulsed DC treatment for high-grade glioma patients: evidence from a meta-analysis.
المؤلفون: Jun-Xia Cao, Xiao-Yan Zhang, Jin-Long Liu, Duo Li, Jun-Li Li, Yi-Shan Liu, Min Wang, Bei-Lei Xu, Hai-Bo Wang, Zheng-Xu Wang
المصدر: PLoS ONE, Vol 9, Iss 9, p e107173 (2014)
بيانات النشر: Public Library of Science (PLoS), 2014.
سنة النشر: 2014
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: BACKGROUND:The effectiveness of immunotherapy for high-grade glioma (HGG) patients remains controversial. To evaluate the therapeutic efficacy of dendritic cells (DCs) alone in the treatment of HGG, we performed a systematic review and meta-analysis in terms of patient survival with relevant published clinical studies. MATERIALS AND METHODS:A total of 409 patients, including historical cohorts, nonrandomized and randomized controls with HGG, were selected for the meta-analysis. RESULTS:The treatment of HGG with DCs was associated with a significantly improved one-year survival (OS) (p0.05), whereas CD56+ lymphocyte subset were significantly increased after DC treatment (p = 0.0001). Furthermore, the levels of IFN-γ in the peripheral blood of HGG patients, which reflect the immune function of the patients, were significantly increased after DC immunotherapy (p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC4162602?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0107173
URL الوصول: https://doaj.org/article/fadfac2f91e64fe291f1b28205f64851
رقم الأكسشن: edsdoj.fadfac2f91e64fe291f1b28205f64851
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0107173