دورية أكاديمية
Caspase-12 and the inflammatory response to Yersinia pestis.
| العنوان: | Caspase-12 and the inflammatory response to Yersinia pestis. |
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| المؤلفون: | Bart Ferwerda, Matthew B B McCall, Maaike C de Vries, Joost Hopman, Boubacar Maiga, Amagana Dolo, Ogobara Doumbo, Modibo Daou, Dirk de Jong, Leo A B Joosten, Rudi A Tissingh, Frans A G Reubsaet, Robert Sauerwein, Jos W M van der Meer, André J A M van der Ven, Mihai G Netea |
| المصدر: | PLoS ONE, Vol 4, Iss 9, p e6870 (2009) |
| بيانات النشر: | Public Library of Science (PLoS), 2009. |
| سنة النشر: | 2009 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | BACKGROUND: Caspase-12 functions as an antiinflammatory enzyme inhibiting caspase-1 and the NOD2/RIP2 pathways. Due to increased susceptibility to sepsis in individuals with functional caspase-12, an early-stop mutation leading to the loss of caspase-12 has replaced the ancient genotype in Eurasia and a significant proportion of individuals from African populations. In African-Americans, it has been shown that caspase-12 inhibits the pro-inflammatory cytokine production. METHODOLOGY/PRINCIPAL FINDINGS: We assessed whether similar mechanisms are present in African individuals, and whether evolutionary pressures due to plague may have led to the present caspase-12 genotype population frequencies. No difference in cytokine induction through the caspase-1 and/or NOD2/RIP2 pathways was observed in two independent African populations, among individuals with either an intact or absent caspase-12. In addition, stimulations with Yersinia pestis and two other species of Yersinia were preformed to investigate whether caspase-12 modulates the inflammatory reaction induced by Yersinia. We found that caspase-12 did not modulate cytokine production induced by Yersinia spp. CONCLUSIONS: Our experiments demonstrate for the first time the involvement of the NOD2/RIP2 pathway for recognition of Yersinia. However, caspase-12 does not modulate innate host defense against Y. pestis and alternative explanations for the geographical distribution of caspase-12 should be sought. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1932-6203 |
| Relation: | http://europepmc.org/articles/PMC2730527?pdf=render; https://doaj.org/toc/1932-6203 |
| DOI: | 10.1371/journal.pone.0006870 |
| URL الوصول: | https://doaj.org/article/faed8cf463554ff9a2e53058ef784950 |
| رقم الأكسشن: | edsdoj.faed8cf463554ff9a2e53058ef784950 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0006870 |