دورية أكاديمية
The Effectiveness of Hydroxychloroquine Versus Hydroxychloroquine Plus Lopinavir/Ritonavir Therapy in SARSCoV- 2 Pneumonia
| العنوان: | The Effectiveness of Hydroxychloroquine Versus Hydroxychloroquine Plus Lopinavir/Ritonavir Therapy in SARSCoV- 2 Pneumonia |
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| المؤلفون: | Ayşe BATIREL, Selda TEKİN, Halit BATIREL, Çiğdem AKALAN KUYUMCU, Nurten BAKAN |
| المصدر: | Mediterranean Journal of Infection, Microbes and Antimicrobials, Vol 10, Iss 1 (2021) |
| بيانات النشر: | Galenos Yayinevi, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine LCC:Infectious and parasitic diseases |
| مصطلحات موضوعية: | sars-cov 2, covid-19, treatment, hydroxychloroquine, lopinavir/ritonavir, Medicine, Infectious and parasitic diseases, RC109-216 |
| الوصف: | Introduction: There is no specific antiviral treatment with proven efficacy and safety in the management of Coronavirus disease-2019 (COVID-19). We aimed to compare the effectiveness of hydroxychloroquine (HQ) monotherapy and HQ-lopinavir/ritonavir (Lpv/r) combined therapy in patients with laboratory-confirmed COVID-19 and to determine the independent factors predicting mortality. Materials and Methods: Retrospective observational multi-centered cohort study. Results: In total, 151 patients (mean age 61±17 years, 66% male) with COVID-19 pneumonia were included: 68 patients received combination therapy, i.e., Lpv/r in addition to HQ, and 83 patients received only HQ. The patients in both groups were similar regarding the majority of baseline variables except for white blood cell count, procalcitonin, lactate dehydrogenase levels, intensive care unit (ICU) admission rates, which were significantly higher, and decreased oxygen saturation in the combination group. The mean duration of symptoms and hospital stay were 5.6±2.3 days and 12.7±9.4 days, respectively. Nearly 43% (n=65) of patients were admitted to the ICU. Patients in the HQ monotherapy group had a shorter stay in hospital than those in the combination group (10 vs. 16 days, p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Turkish |
| تدمد: | 2147-673X |
| Relation: | http://mjima.org/abstract.php?id=225; https://doaj.org/toc/2147-673X |
| DOI: | 10.4274/mjima.galenos.2021.2020.8 |
| URL الوصول: | https://doaj.org/article/fb12e210c7804ac19e76f9dde8abebee |
| رقم الأكسشن: | edsdoj.fb12e210c7804ac19e76f9dde8abebee |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2147673X |
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| DOI: | 10.4274/mjima.galenos.2021.2020.8 |