دورية أكاديمية
RGS14 Regulation of Post-Synaptic Signaling and Spine Plasticity in Brain
| العنوان: | RGS14 Regulation of Post-Synaptic Signaling and Spine Plasticity in Brain |
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| المؤلفون: | Nicholas H. Harbin, Sara N. Bramlett, Carolina Montanez-Miranda, Gizem Terzioglu, John R. Hepler |
| المصدر: | International Journal of Molecular Sciences, Vol 22, Iss 13, p 6823 (2021) |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | RGS protein, RGS14, synaptic plasticity, G protein, H-Ras, calcium, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | The regulator of G-protein signaling 14 (RGS14) is a multifunctional signaling protein that regulates post synaptic plasticity in neurons. RGS14 is expressed in the brain regions essential for learning, memory, emotion, and stimulus-induced behaviors, including the basal ganglia, limbic system, and cortex. Behaviorally, RGS14 regulates spatial and object memory, female-specific responses to cued fear conditioning, and environmental- and psychostimulant-induced locomotion. At the cellular level, RGS14 acts as a scaffolding protein that integrates G protein, Ras/ERK, and calcium/calmodulin signaling pathways essential for spine plasticity and cell signaling, allowing RGS14 to naturally suppress long-term potentiation (LTP) and structural plasticity in hippocampal area CA2 pyramidal cells. Recent proteomics findings indicate that RGS14 also engages the actomyosin system in the brain, perhaps to impact spine morphogenesis. Of note, RGS14 is also a nucleocytoplasmic shuttling protein, where its role in the nucleus remains uncertain. Balanced nuclear import/export and dendritic spine localization are likely essential for RGS14 neuronal functions as a regulator of synaptic plasticity. Supporting this idea, human genetic variants disrupting RGS14 localization also disrupt RGS14’s effects on plasticity. This review will focus on the known and unexplored roles of RGS14 in cell signaling, physiology, disease and behavior. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/22/13/6823; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms22136823 |
| URL الوصول: | https://doaj.org/article/dfb2191441104260b84f1ab99e11d8bb |
| رقم الأكسشن: | edsdoj.fb2191441104260b84f1ab99e11d8bb |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms22136823 |