دورية أكاديمية
The lncRNAs at X Chromosome Inactivation Center: Not Just a Matter of Sex Dosage Compensation
| العنوان: | The lncRNAs at X Chromosome Inactivation Center: Not Just a Matter of Sex Dosage Compensation |
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| المؤلفون: | Chiara Siniscalchi, Armando Di Palo, Aniello Russo, Nicoletta Potenza |
| المصدر: | International Journal of Molecular Sciences, Vol 23, Iss 2, p 611 (2022) |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | ceRNET, microRNA, lncRNA, X chromosome inactivation, Turner syndrome, Klinefelter syndrome, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Non-coding RNAs (ncRNAs) constitute the majority of the transcriptome, as the result of pervasive transcription of the mammalian genome. Different RNA species, such as lncRNAs, miRNAs, circRNA, mRNAs, engage in regulatory networks based on their reciprocal interactions, often in a competitive manner, in a way denominated “competing endogenous RNA (ceRNA) networks” (“ceRNET”): miRNAs and other ncRNAs modulate each other, since miRNAs can regulate the expression of lncRNAs, which in turn regulate miRNAs, titrating their availability and thus competing with the binding to other RNA targets. The unbalancing of any network component can derail the entire regulatory circuit acting as a driving force for human diseases, thus assigning “new” functions to “old” molecules. This is the case of XIST, the lncRNA characterized in the early 1990s and well known as the essential molecule for X chromosome inactivation in mammalian females, thus preventing an imbalance of X-linked gene expression between females and males. Currently, literature concerning XIST biology is becoming dominated by miRNA associations and they are also gaining prominence for other lncRNAs produced by the X-inactivation center. This review discusses the available literature to explore possible novel functions related to ceRNA activity of lncRNAs produced by the X-inactivation center, beyond their role in dosage compensation, with prospective implications for emerging gender-biased functions and pathological mechanisms. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/23/2/611; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms23020611 |
| URL الوصول: | https://doaj.org/article/dfb4def861334bdf80d7af3c97746f18 |
| رقم الأكسشن: | edsdoj.fb4def861334bdf80d7af3c97746f18 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms23020611 |