دورية أكاديمية
TPO antibody status prior to first radioactive iodine therapy as a predictive parameter for hypothyroidism in Graves’ disease
| العنوان: | TPO antibody status prior to first radioactive iodine therapy as a predictive parameter for hypothyroidism in Graves’ disease |
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| المؤلفون: | Sébastien Verdickt, Falco Van Nes, Carolien Moyson, Toon Maes, Paul Van Crombrugge, Annick Van den Bruel, Brigitte Decallonne |
| المصدر: | European Thyroid Journal, Vol 11, Iss 4, Pp 1-8 (2023) |
| بيانات النشر: | Bioscientifica, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Diseases of the endocrine glands. Clinical endocrinology |
| مصطلحات موضوعية: | thyroid peroxidase antibodies, graves’ disease, radioactive iodine therapy, hypothyroidism, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| الوصف: | Objective: We investigated whether a positive thyroid peroxidase antibody (TPO Ab) status before radioactive iodine (RAI) therapy in patients with Graves’ hyperthyroidism is a predictive factor for developing hypothyroidism post RAI. Methods: We performed a retrospective study of patients with Graves’ hyperthyroidism with known TPO Ab status, receiving the first administration of RAI. Patients from four thyroid outpatient centres in Belgium receiving their first RAI therapy between the years 2011 and 2019 were studied. Clinical, laboratory, imaging, and treatment data were recorded from medical charts. Hypothyroidism and cure (defined as combined hypo- and euthyroidism) were evaluated in period 1 (≥2 and ≤9 months, closest to 6 months post RAI) and period 2 (>9 months and ≤24 months post RAI, closest to 12 months post RAI). Results: A total of 152 patients were included of which 105 (69%) were TPO Ab-positive. Compared to TPO Ab-negative patients, TPO Ab-positive patients were younger, had a larger thyroid gland, and had more previous episodes of hyperthyroidism. In period 1, 89% of the TPO Ab-positive group developed hypothyroidism and 72% in the TPO Ab-negative group (P = 0.007). In period 2, the observation was similar: 88% vs 72% (P = 0.019). In the multivariate logistic regression analysis, a positive TPO Ab status was associated with hypothyroidism in period 2 (adjusted OR: 4.78; 95% CI: 1.27–20.18; P = 0.024). In period 1, the aOR was 4.16 (95% CI: 1.0–18.83; P = 0.052). Conclusion: A positive TPO Ab status in patients with Graves’ hyperthyroidism receiving the first administration of RAI is associated with a higher risk of early hypothyroidism. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2235-0802 89376412 |
| Relation: | https://etj.bioscientifica.com/view/journals/etj/11/4/ETJ-22-0047.xml; https://doaj.org/toc/2235-0802 |
| DOI: | 10.1530/ETJ-22-0047 |
| URL الوصول: | https://doaj.org/article/fb89376412624e37905a77553dfbac90 |
| رقم الأكسشن: | edsdoj.fb89376412624e37905a77553dfbac90 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22350802 89376412 |
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| DOI: | 10.1530/ETJ-22-0047 |