دورية أكاديمية
Botulinum Toxin Therapy: A Series of Clinical Studies on Patients with Spasmodic Dysphonia in Japan
| العنوان: | Botulinum Toxin Therapy: A Series of Clinical Studies on Patients with Spasmodic Dysphonia in Japan |
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| المؤلفون: | Masamitsu Hyodo, Kento Asano, Asuka Nagao, Kahori Hirose, Maya Nakahira, Saori Yanagida, Noriko Nishizawa |
| المصدر: | Toxins, Vol 13, Iss 12, p 840 (2021) |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | spasmodic dysphonia, nationwide survey, diagnostic criteria, severity grading, placebo-controlled double-blind clinical trial, Medicine |
| الوصف: | Spasmodic dysphonia (SD) is a rare voice disorder caused by involuntary and intermittent spasms of the laryngeal muscles. Both diagnosis and treatment have been controversial. Therefore, a series of clinical studies has recently been conducted in Japan. A nationwide epidemiological survey revealed that adductor SD predominated (90–95% of all cases; 3.5–7.0/100,000), principally among young women in their 20s and 30s. To facilitate early diagnosis, we created diagnostic criteria for SD and a severity grading system. The diagnostic criteria include the principal and accompanying symptoms, clinical findings during phonation, the treatment response, and the differential diagnoses. The severity grade is determined using a combination of subjective and objective assessments. Botulinum toxin (BT) injection is the treatment of choice; however, there have been few high-quality clinical studies and BT has been used off-label. We conducted a placebo-controlled, randomized, double-blinded clinical trial of BT therapy; this was effective and safe. BT treatment is now funded by the Japanese medical insurance scheme. Studies thus far have facilitated early diagnosis and appropriate therapy; they have fostered patient awareness of SD. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 13120840 2072-6651 |
| Relation: | https://www.mdpi.com/2072-6651/13/12/840; https://doaj.org/toc/2072-6651 |
| DOI: | 10.3390/toxins13120840 |
| URL الوصول: | https://doaj.org/article/fbaf45fb4d4e4ac0bbcd2adcb8d85004 |
| رقم الأكسشن: | edsdoj.fbaf45fb4d4e4ac0bbcd2adcb8d85004 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 13120840 20726651 |
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| DOI: | 10.3390/toxins13120840 |