دورية أكاديمية
Does curcumin or metformin attenuate oxidative stress and diabetic nephropathy in rats?
| العنوان: | Does curcumin or metformin attenuate oxidative stress and diabetic nephropathy in rats? |
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| المؤلفون: | Soheila Asadi, Mohammad Taghi Goodarzi, Jamshid Karimi, Mohammad Hashemnia, Iraj Khodadadi |
| المصدر: | Journal of Nephropathology, Vol 8, Iss 1, Pp e08-e08 (2019) |
| بيانات النشر: | Society of Diabetic Nephropathy Prevention, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Pathology LCC:Internal medicine LCC:Other systems of medicine |
| مصطلحات موضوعية: | curcumin, diabetic nephropathies, metformin, oxidative stress, diabetic kidney disease, reactive oxygen species, Pathology, RB1-214, Internal medicine, RC31-1245, Other systems of medicine, RZ201-999 |
| الوصف: | Background: Since the importance of oxidative stress in the development of diabetic nephropathy (DN) has previously been established, the therapeutic effects of various natural antioxidant agents or synthetic drugs have so far been investigated. Objectives: The aim of this study was to investigate the beneficial effects of curcumin (a natural polyphenol) and metformin (a common therapeutic medicine for type 2 diabetes) on oxidative status in kidney of type 1 diabetic rats. Materials and Methods: In this experimental study 60 male Wistar rats were divided into 10 groups. Type 1 diabetes was induced by streptozotocin. Rats received chow diet and treated with either normal saline in control (N) and diabetic control (D) groups or different doses of metformin (Met) (300 or 500 mg/kg body weight) or curcumin (Cur) (50 or 150 mg/kg body weight) in N+Met300, N+Met500, N+Cur50, N+Cur150, D+Met300, D+Met500, D+Cur50, and D+Cur150 groups. Urinary creatinine, urea, and protein were measured. Total antioxidant capacity (TAC), total oxidant status (TOS), malondialdehyde (MDA), and the activity of superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase were assessed in kidney tissues. Results: Both metformin and curcumin showed significant effects on urinary creatinine, urea, and protein levels (P value for all was |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2251-8363 2251-8819 |
| Relation: | https://nephropathol.com/PDF/jnp-8-08.pdf; https://doaj.org/toc/2251-8363; https://doaj.org/toc/2251-8819 |
| DOI: | 10.15171/jnp.2019.08 |
| URL الوصول: | https://doaj.org/article/fbe521dd20a14e6bb1efe13eabd00b3f |
| رقم الأكسشن: | edsdoj.fbe521dd20a14e6bb1efe13eabd00b3f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22518363 22518819 |
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| DOI: | 10.15171/jnp.2019.08 |