دورية أكاديمية
أعرض في EDS

Serum Soluble ST2 Correlated with Symptom Severity and Clinical Response of Sublingual Immunotherapy for House Dust Mite-Induced Allergic Rhinitis Patients

التفاصيل البيبلوغرافية
العنوان: Serum Soluble ST2 Correlated with Symptom Severity and Clinical Response of Sublingual Immunotherapy for House Dust Mite-Induced Allergic Rhinitis Patients
المؤلفون: Kang Zhu, Cui Xia, Jingguo Chen, Chao Yu, Tianxi Gao, Jing Yan, Na Shao, Pin Zhu, Bin Sun, Xiaoyong Ren, Yanni Zhang
المصدر: Mediators of Inflammation, Vol 2021 (2021)
بيانات النشر: Wiley, 2021.
سنة النشر: 2021
المجموعة: LCC:Pathology
مصطلحات موضوعية: Pathology, RB1-214
الوصف: Background. Suppressor of tumorigenicity 2 (ST2) is a key biomarker in inflammation and cardiovascular diseases, but limited data is available on its role in allergic rhinitis (AR). Objective. The aim of this study is to explore the role of serum soluble ST2 (sST2) in evaluating disease severity and predicting the efficacy of sublingual immunotherapy (SLIT) in house dust mite- (HDM-) induced AR patients. Methods. Eighty healthy controls (HC group) and 160 HDM-induced AR patients, including 40 mild patients (MAR group) and 120 moderate-severe patients (MSAR group), were recruited in this study. Serum was collected from all participants and levels of sST2 were determined by ELISA and the relationship between sST2 levels and disease severity was assessed. In the MSAR group, 109 patients received 3 years of SLIT, and the relationship between serum levels of sST2 and efficacy of SLIT was exampled. Results. Serum sST2 levels were increased in HDM-induced AR patients compared to the HC group (P0.05). Receiver operating characteristic (ROC) curve showed promising accuracy for predicting clinical efficacy of SLIT in AR patients (area under the curve=0.839, P
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 0962-9351
1466-1861
Relation: https://doaj.org/toc/0962-9351; https://doaj.org/toc/1466-1861
DOI: 10.1155/2021/5576596
URL الوصول: https://doaj.org/article/fc227d814dac458cb693b8a55fd0c5b5
رقم الأكسشن: edsdoj.fc227d814dac458cb693b8a55fd0c5b5
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:09629351
14661861
DOI:10.1155/2021/5576596