دورية أكاديمية
A Cytotoxic Rocaglate Compound from The Stembark of Aglaia argentea (Meliaceae)
| العنوان: | A Cytotoxic Rocaglate Compound from The Stembark of Aglaia argentea (Meliaceae) |
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| المؤلفون: | Ace Tatang Hidayat, Kindi Farabi, Desi Harneti, Nurlelasari Nurlelasari, Rani Maharani, Tri Mayanti, Unang Supratman, Yoshihito Shiono |
| المصدر: | Molekul, Vol 12, Iss 2, Pp 146-152 (2017) |
| بيانات النشر: | Jenderal Soedirman University, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Chemistry |
| مصطلحات موضوعية: | Aglaia, Aglaia argentea, methyl rocaglate, cytotoxic activity, P-388 murine leukemia cells, Chemistry, QD1-999 |
| الوصف: | The Aglaia genus belong to Meliceae family is unique plant species because the presence of rocaglate and rocaglamide which is so far isolated only from Aglaia genus, indicate that type of this compound as a chemical marker for the genus of Aglaia. This type of compound known to have strong activity, such as insecticide and cytotoxic. This study describe the isolation, structure elucidation, and cytotoxic activity of an isolated rocaglate compound. Dried stembark of A. argentea extracted with methanol and partition between n-hexane, ethyl acetate, and n-butanol, respectively The extracts were tested against P-388 murine leukemia cells and the ethyl acetat showed strongest activity with IC50 value of 15.5 mg/mL. The ethyl acetate then was separated and purified with chromatography technique to obtain isolated compound 1. The chemical structure of isolated compounds were elucidated by spectroscopic methods including one and two-dimensional NMR as well as high-resolution mass spectrometric analysis and identified as a methyl rocaglate. Compound 1 showed strong cytotoxic activity with an IC50 value of < 0.1 μg/mL. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Indonesian |
| تدمد: | 1907-9761 2503-0310 |
| Relation: | https://ojs.jmolekul.com/ojs/index.php/jm/article/view/361; https://doaj.org/toc/1907-9761; https://doaj.org/toc/2503-0310 |
| DOI: | 10.20884/1.jm.2017.12.2.361 |
| URL الوصول: | https://doaj.org/article/cafc24dcefca43f48df43d0968078208 |
| رقم الأكسشن: | edsdoj.fc24dcefca43f48df43d0968078208 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19079761 25030310 |
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| DOI: | 10.20884/1.jm.2017.12.2.361 |