دورية أكاديمية
Epstein-Barr virus induces erosive arthritis in humanized mice.
| العنوان: | Epstein-Barr virus induces erosive arthritis in humanized mice. |
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| المؤلفون: | Yoshikazu Kuwana, Masami Takei, Misako Yajima, Ken-ichi Imadome, Hirotake Inomata, Masaaki Shiozaki, Natsumi Ikumi, Takamasa Nozaki, Hidetaka Shiraiwa, Noboru Kitamura, Jin Takeuchi, Shigemasa Sawada, Naoki Yamamoto, Norio Shimizu, Mamoru Ito, Shigeyoshi Fujiwara |
| المصدر: | PLoS ONE, Vol 6, Iss 10, p e26630 (2011) |
| بيانات النشر: | Public Library of Science (PLoS), 2011. |
| سنة النشر: | 2011 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Epstein-Barr virus (EBV) has been implicated in the pathogenesis of rheumatoid arthritis (RA) on the basis of indirect evidence, such as its presence in affected joint tissues, antigenic cross reactions between EBV and human proteins, and elevated humoral and cellular anti-EBV immune responses in patients. Here we report development of erosive arthritis closely resembling RA in humanized mice inoculated with EBV. Human immune system components were reconstituted in mice of the NOD/Shi-scid/IL-2Rγ(null) (NOG) strain by transplantation with CD34(+) hematopoietic stem cells isolated from cord blood. These humanized mice were then inoculated with EBV and examined pathologically for the signs of arthritis. Erosive arthritis accompanied by synovial membrane proliferation, pannus formation, and bone marrow edema developed in fifteen of twenty-three NOG mice transplanted with human HSC and inoculated with EBV, but not in the nine NOG mice that were transplanted with HSC but not inoculated with EBV. This is the first report of an animal model of EBV-induced arthritis and strongly suggest a causative role of the virus in RA. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1932-6203 |
| Relation: | http://europepmc.org/articles/PMC3197576?pdf=render; https://doaj.org/toc/1932-6203 |
| DOI: | 10.1371/journal.pone.0026630 |
| URL الوصول: | https://doaj.org/article/fc2e60aa89bc4bd4a6d5f28627f19275 |
| رقم الأكسشن: | edsdoj.fc2e60aa89bc4bd4a6d5f28627f19275 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0026630 |