دورية أكاديمية
Pharmacokinetic Analysis of Four Bioactive Iridoid and Secoiridoid Glycoside Components of Radix Gentianae Macrophyllae and Their Synergistic Excretion by HPLC-DAD Combined with Second-Order Calibration
| العنوان: | Pharmacokinetic Analysis of Four Bioactive Iridoid and Secoiridoid Glycoside Components of Radix Gentianae Macrophyllae and Their Synergistic Excretion by HPLC-DAD Combined with Second-Order Calibration |
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| المؤلفون: | Tian-Ming Yang, Yang-Xi Liu, Hai-Yan Fu, Wei Lan, Han-Bo Su, He-Bin Tang, Qiao-Bo Yin, He-Dong Li, Li-Ping Wang, Hai-Long Wu |
| المصدر: | Natural Products and Bioprospecting, Vol 7, Iss 6, Pp 445-459 (2017) |
| بيانات النشر: | SpringerOpen, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Botany |
| مصطلحات موضوعية: | Radix Gentianae Macrophyllae, HPLC-DAD, Second-order calibration, Pharmacokinetic analysis, Botany, QK1-989 |
| الوصف: | Abstract An HPLC-DAD method combined with second-order calibration based on the alternating trilinear decomposition (ATLD) algorithm with the aid of region selection was developed to simultaneously and quantitatively characterize the synergistic relationships and cumulative excretion of the four bioactive ingredients of Radix Gentianae Macrophyllae in vivo. Although the analytes spectra substantially overlapped with that of the biological matrix, the overlapping profiles between analytes and co-eluting interferences can be successfully separated and accurately quantified by the ATLD method on the basis of the strength of region selection. The proposed approach not only determined the content change but also revealed the synergistic relationships and the cumulative excretion in vivo of the four ingredients in urine and feces samples collected at different excretion time intervals. In addition, several statistical parameters were employed to evaluate the accuracy and precision of the method. Quantitative results were confirmed by HPLC-mass spectrometry. Satisfactory results indicated that the proposed approach can be utilized to investigate the pharmacokinetics of Radix Gentianae Macrophyllae excretion in vivo. Graphical Abstract |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2192-2195 2192-2209 |
| Relation: | http://link.springer.com/article/10.1007/s13659-017-0145-7; https://doaj.org/toc/2192-2195; https://doaj.org/toc/2192-2209 |
| DOI: | 10.1007/s13659-017-0145-7 |
| URL الوصول: | https://doaj.org/article/fc4ec254922f465d8c5bc36aede74879 |
| رقم الأكسشن: | edsdoj.fc4ec254922f465d8c5bc36aede74879 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 21922195 21922209 |
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| DOI: | 10.1007/s13659-017-0145-7 |