دورية أكاديمية
Vitamin D Pathway Genes, Diet, and Risk of Renal Cell Carcinoma
| العنوان: | Vitamin D Pathway Genes, Diet, and Risk of Renal Cell Carcinoma |
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| المؤلفون: | S. Karami, P. Brennan, M. Navratilova, D. Mates, D. Zaridze, V. Janout, H. Kollarova, V. Bencko, V. Matveev, N. Szesznia-Dabrowska, I. Holcatova, M. Yeager, S. Chanock, N. Rothman, P. Boffetta, W-H. Chow, L. E. Moore |
| المصدر: | International Journal of Endocrinology, Vol 2010 (2010) |
| بيانات النشر: | Wiley, 2010. |
| سنة النشر: | 2010 |
| المجموعة: | LCC:Diseases of the endocrine glands. Clinical endocrinology |
| مصطلحات موضوعية: | Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| الوصف: | Mediated by binding to the high-affinity vitamin D receptor (VDR), vitamin D forms a heterodimer complex with the retinoid-X-receptor (RXR). Variation in both genes has been shown to modify renal cell carcinoma (RCC) risk. Therefore, we investigated whether VDR and RXRA polymorphisms modify associations between RCC risk and frequency of dietary intake of vitamin D and calcium rich foods, and occupational ultraviolet exposure among 777 RCC case and 1035 controls from Central and Eastern Europe. A positive association was observed in this population between increasing dietary intake frequency of yogurt, while an inverse association was observed with egg intake frequency. RXRA polymorphisms, located 3′ of the coding sequence, modified associations between specific vitamin D rich foods and RCC risk, while RXRA polymorphisms, located in introns 1 and 4, modified associations with specific calcium rich foods. Results suggest that variants in the RXRA gene modified the associations observed between RCC risk and calcium and vitamin D intake. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1687-8337 1687-8345 |
| Relation: | https://doaj.org/toc/1687-8337; https://doaj.org/toc/1687-8345 |
| DOI: | 10.1155/2010/879362 |
| URL الوصول: | https://doaj.org/article/fc79733b8b234c8ea00ef698710145e3 |
| رقم الأكسشن: | edsdoj.fc79733b8b234c8ea00ef698710145e3 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16878337 16878345 |
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| DOI: | 10.1155/2010/879362 |