دورية أكاديمية
The clinical implications of serum ferritin in Kawasaki disease: a helpful biomarker for evaluating therapeutic responsiveness, coronary artery involvement and the tendency of macrophage activation syndrome
| العنوان: | The clinical implications of serum ferritin in Kawasaki disease: a helpful biomarker for evaluating therapeutic responsiveness, coronary artery involvement and the tendency of macrophage activation syndrome |
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| المؤلفون: | Zhen Qiu, Hui Hui Liu, Guo Zhen Fan, Wei Xia Chen, Peng Hu |
| المصدر: | Archives of Medical Science, Vol 18, Iss 1, Pp 267-274 (2021) |
| بيانات النشر: | Termedia Publishing House, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | coronary arteritis, intravenous immunoglobulin, kawasaki disease, macrophage activation syndrome, serum ferritin, Medicine |
| الوصف: | Introduction Serum ferritin (SF) is an acute-phase reactant in inflammatory diseases. Our aim was to analyze the clinical implications of SF in Kawasaki disease (KD). Material and methods 244 KD children were divided into 6 subgroups. SF, inflammatory mediators and blood cell counts were detected. Results (1) SF dramatically increased in the acute phase of KD and maintained after IVIG therapy; (2) SF increased in IVIG-nonresponsive KD patients (AUC = 0.705; sensitivity: 57.10%; specificity: 82.90%); SF positively correlated with the internal diameter of the coronary artery (AUC = 0.603; sensitivity: 92.30%; specificity: 37.70%); (3) SF increased in 4 patients with the macrophage activation syndrome (MAS)/MAS tendency (979.03 ±474.19 µg/l). Conclusions SF is implied to be a helpful biomarker for forecasting IVIG-nonresponsive KD, coronary artery abnormalities (CAAs) and MAS tendency. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1734-1922 1896-9151 |
| Relation: | https://www.archivesofmedicalscience.com/The-clinical-implications-of-serum-ferritin-in-Kawasaki-disease-a-helpful-biomarker,144293,0,2.html; https://doaj.org/toc/1734-1922; https://doaj.org/toc/1896-9151 |
| DOI: | 10.5114/aoms/144293 |
| URL الوصول: | https://doaj.org/article/fc9c9c52c6674c7d9c289f04d8933397 |
| رقم الأكسشن: | edsdoj.fc9c9c52c6674c7d9c289f04d8933397 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17341922 18969151 |
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| DOI: | 10.5114/aoms/144293 |