دورية أكاديمية
أعرض في EDS

Case Report: Nivolumab-Induced Autoimmune Pancreatitis

التفاصيل البيبلوغرافية
العنوان: Case Report: Nivolumab-Induced Autoimmune Pancreatitis
المؤلفون: Preeya Goyal, Justin T. Moyers, Bassem G. Elgohary, Muhammad B. Hammami
المصدر: Journal of Immunotherapy and Precision Oncology, Pp 208-211 (2021)
بيانات النشر: Innovative Healthcare Institute, 2021.
سنة النشر: 2021
المجموعة: LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
LCC:Immunologic diseases. Allergy
مصطلحات موضوعية: immunotherapy, melanoma, pancreatitis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Immunologic diseases. Allergy, RC581-607
الوصف: Nivolumab is an anti-programmed cell death protein 1 monoclonal antibody. While an effective treatment for a variety of tumors, immune checkpoint inhibitors (ICI) can cause immune-related adverse events such as ICI-pancreatic injury (ICI-PI). Here we present a case of a 60-year-old man with metastatic acral melanoma treated with nivolumab and ipilimumab who developed ICI-PI. Changes in positron emission tomography images preceded symptom onset. However, this case is unique in that the patient presented with cholestatic liver disease. Magnetic resonance cholangiopancreatography showed a dilated extrahepatic bile duct that resolved with steroid therapy, similar to the clinical course of autoimmune pancreatitis. ICI-PI has variable presentations including obstructive jaundice with a clinical course mimicking autoimmune pancreatitis and prompt awareness and treatment of ICI-PI is clinically significant given increasing use of ICIs.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2666-2345
2590-017X
Relation: https://doaj.org/toc/2666-2345; https://doaj.org/toc/2590-017X
DOI: 10.36401/JIPO-21-11
URL الوصول: https://doaj.org/article/fccb69b21f7946cbb137803d5962c322
رقم الأكسشن: edsdoj.fccb69b21f7946cbb137803d5962c322
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:26662345
2590017X
DOI:10.36401/JIPO-21-11