دورية أكاديمية
Beneficial effects of protocatechuic acid on diabetic retinopathy in streptozocin-induced diabetic rats
| العنوان: | Beneficial effects of protocatechuic acid on diabetic retinopathy in streptozocin-induced diabetic rats |
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| المؤلفون: | Ling Wan, Jun Li, Wei-Bai Chen, Guo-Qiang Wu |
| المصدر: | International Journal of Ophthalmology, Vol 16, Iss 6, Pp 855-862 (2023) |
| بيانات النشر: | Press of International Journal of Ophthalmology (IJO PRESS), 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Ophthalmology |
| مصطلحات موضوعية: | diabetic retinopathy, streptozocin, protocatechuic acid, oxidative stress, vascular endothelial growth factor, Ophthalmology, RE1-994 |
| الوصف: | AIM: To determine the effects of protocatechuic acid (PCA) on streptozocin-induced diabetic retinopathy (DR) in rats. METHODS: Wistar rats were given a 50 mg/kg intraperitoneal injection of streptozocin to induce diabetes. Animals were assigned randomly one of four groups (8 rats per group): control, diabetic, diabetic plus PCA (25 mg/kg•d), and diabetic plus PCA (50 mg/kg•d). After inducing diabetes, treatments were started one week later and continued for eight weeks. After the experiment, the rats were sacrificed, and their retinas were taken for biochemical and molecular analysis. RESULTS: PCA administration diminished the blood glucose and glycated haemoglobin levels relative to the diabetic group. In diabetic rats, PCA lowered elevated levels of advanced glycosylated end products (AGEs) and receptor for AGEs (RAGE). In the retina of diabetic rats, PCA effectively decreased inflammatory cytokine, nuclear factor-κB, tumour necrosis factor-α, interleukin-1β, and vascular endothelial growth factor, and increased antioxidant markers glutathione, superoxide dismutase, and catalase. CONCLUSION: The protective benefits of PCA against DR may be attributable to its suppression of the AGEs and RAGE and its antioxidant and anti-inflammatory properties. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2222-3959 2227-4898 |
| Relation: | http://ies.ijo.cn/en_publish/2023/6/20230604.pdf; https://doaj.org/toc/2222-3959; https://doaj.org/toc/2227-4898 |
| DOI: | 10.18240/ijo.2023.06.04 |
| URL الوصول: | https://doaj.org/article/fd410325073046cfad28ff85eefa9d34 |
| رقم الأكسشن: | edsdoj.fd410325073046cfad28ff85eefa9d34 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22223959 22274898 |
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| DOI: | 10.18240/ijo.2023.06.04 |