دورية أكاديمية
The Association of Interleukin-17 and ACCP levels with Rheumatoid arthritis patients and Control Groups
| العنوان: | The Association of Interleukin-17 and ACCP levels with Rheumatoid arthritis patients and Control Groups |
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| المؤلفون: | Haneen Jassim, Thanaa Al-Turaihi |
| المصدر: | مجلة الكوفة الطبية, Vol 19, Iss 2 (2023) |
| بيانات النشر: | Faculty of Medicine, University of Kufa, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | Anti-cyclic citrullinated peptide (ACCP), Disease Activity Score 28 (DAS28), Interleukin-17 (IL-17), periodontal disease, Rheumatoid arthritis., Medicine |
| الوصف: | Background: Rheumatoid arthritis (RA) represents the prevailing form of chronic inflammatory polyarthritis, characterized by an autoimmune response directed against citrullinated antigens and subsequent synovial joint destruction. The susceptibility to RA appears to be influenced by a complex interplay between a specific immune response to various environmental factors and a favorable genetic predisposition. IL-17 Association with Diseases found to be elevated in various chronic inflammatory conditions including RA especially in cases resistant to anti-TNF therapy. Aim : To investigate the value of IL-17 and ACCP levels with study groups as well as the association of chronic periodontal disease as an environmental risk factor of RA. Methods : This case-control study involved a total of 140 participants were enrolled, with 70 individuals meeting specific criteria and serological testing confirming their RA diagnosis, while the remaining 70 served as healthy controls.The study involved the collection of blood samples from the participants. Various measurements and tests were conducted, including the assessment of disease activity using the Disease Activity Score (DAS28-ESR) and erythrocyte sedimentation rate (ESR), detection of RF through latex agglutination, quantification of anti-cyclic citrullinated peptide (ACCP) and interleukin-17 (IL-17) levels via enzyme-linked immunosorbent assay (ELISA). Results : RA patients exhibited substantially higher values for ESR, RF, ACCP compared to the control group. Also IL-17 substantially higher values for RA patients Notably, the p-values for ESR, ACCP, and IL-17 were 0.0001, 0.02, and 0.0001, respectively, indicating strong statistical significance. patients who had gum problems were 43(61.4 %) while the control group was 9 (12.5%) had a gum problem Statistically, parameter had significant differences (p.value=0.0001). |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1993-517X 2709-4464 |
| Relation: | https://journal.uokufa.edu.iq/index.php/kmj/article/view/13050; https://doaj.org/toc/1993-517X; https://doaj.org/toc/2709-4464 |
| DOI: | 10.36330/kmj.v19i2.13050 |
| URL الوصول: | https://doaj.org/article/dedfd54e4ccc4c36a173a08bb8674d27 |
| رقم الأكسشن: | edsdoj.fd54e4ccc4c36a173a08bb8674d27 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 1993517X 27094464 |
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| DOI: | 10.36330/kmj.v19i2.13050 |