دورية أكاديمية
Effects of novel quinoid thiosulfonate derivative on ADP-induced platelet aggregation
| العنوان: | Effects of novel quinoid thiosulfonate derivative on ADP-induced platelet aggregation |
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| المؤلفون: | T. Halenova, I. Nikolaieva, O. Savchuk, K. Bolibrukh, S. Polovkovych, V. Novikov |
| المصدر: | Vìsnik: Kiïvsʹkij Nacìonalʹnij Unìversitet Imenì Tarasa Ševčenka. Bìologìâ, Vol 68, Iss 3, Pp 36-40 (2016) |
| بيانات النشر: | Taras Shevchenko National University of Kyiv, 2016. |
| سنة النشر: | 2016 |
| المجموعة: | LCC:Biology (General) |
| مصطلحات موضوعية: | platelet rich plasma, quinoid thiosulfonate derivative, ADP-induced platelet aggregation, antiplatelet agents, Biology (General), QH301-705.5 |
| الوصف: | Recently, in a large scale screening test, we have found that S-((1,4-dimethoxy-9,10-dioxo-9,10-dihydroanthracen-2-yl)methyl)4-aminobenzenesulfonothioate, a chemically synthesized thiosulfonate derivative of quinone, possessed an antiplatelet activity. To elucidate the mechanism of its antiplatelet action, a series of experiments were performed. The compound was found to inhibit the ADP-induced platelet aggregation. The inhibitory effect was dose-dependent on concentration and preincubation time. The derivative also disaggregated the preformed platelet aggregates induced by ADP. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Ukrainian |
| تدمد: | 1728-2748 2308-8036 |
| Relation: | http://biovestnik.com/index.php/biology/article/view/26; https://doaj.org/toc/1728-2748; https://doaj.org/toc/2308-8036 |
| DOI: | 10.17721/1728_2748.2014.68.36-40 |
| URL الوصول: | https://doaj.org/article/fd8a339648f84d8dbc78119b94786af7 |
| رقم الأكسشن: | edsdoj.fd8a339648f84d8dbc78119b94786af7 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17282748 23088036 |
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| DOI: | 10.17721/1728_2748.2014.68.36-40 |