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Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling

التفاصيل البيبلوغرافية
العنوان: Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling
المؤلفون: Eman Khatib-Massalha, Suditi Bhattacharya, Hassan Massalha, Adi Biram, Karin Golan, Orit Kollet, Anju Kumari, Francesca Avemaria, Ekaterina Petrovich-Kopitman, Shiri Gur-Cohen, Tomer Itkin, Isabell Brandenburger, Asaf Spiegel, Ziv Shulman, Zachary Gerhart-Hines, Shalev Itzkovitz, Matthias Gunzer, Stefan Offermanns, Ronen Alon, Amiram Ariel, Tsvee Lapidot
المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
بيانات النشر: Nature Portfolio, 2020.
سنة النشر: 2020
المجموعة: LCC:Science
مصطلحات موضوعية: Science
الوصف: Lactate is a by-product of glycolysis that can function via its G protein receptor GPR81. Here the authors show that LPS or Salmonella infection enhances glycolytic metabolism in bone marrow neutrophils, resulting in lactate production, which increases endothelial barrier permeability and mobilization of these neutrophils by targeting endothelial GPR81.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2041-1723
Relation: https://doaj.org/toc/2041-1723
DOI: 10.1038/s41467-020-17402-2
URL الوصول: https://doaj.org/article/fd9905e2c6a74145a36f74cbae797fa7
رقم الأكسشن: edsdoj.fd9905e2c6a74145a36f74cbae797fa7
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20411723
DOI:10.1038/s41467-020-17402-2