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PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation

التفاصيل البيبلوغرافية
العنوان: PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation
المؤلفون: Yilun Sun, Jiji Chen, Shar-yin N. Huang, Yijun P. Su, Wenjie Wang, Keli Agama, Sourav Saha, Lisa M. Jenkins, John M. Pascal, Yves Pommier
المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
بيانات النشر: Nature Portfolio, 2021.
سنة النشر: 2021
المجموعة: LCC:Science
مصطلحات موضوعية: Science
الوصف: TOP1 resolves DNA supercoils by forming cleavage complexes (TOP1cc) that are trapped by TOP1 inhibitors. Here the authors provide insights into the mechanistic understanding of TOP1cc PARylation, showing that inhibition of PARG results in stabilization of TOP1cc PARylation that blocks the proteasomal degradation of TOP1cc.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2041-1723
Relation: https://doaj.org/toc/2041-1723
DOI: 10.1038/s41467-021-25252-9
URL الوصول: https://doaj.org/article/efd9b3f404b3443ca49e78b32652785a
رقم الأكسشن: edsdoj.fd9b3f404b3443ca49e78b32652785a
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20411723
DOI:10.1038/s41467-021-25252-9