دورية أكاديمية
أعرض في EDS

Association of Alpha B-Crystallin Expression with Tumor Differentiation Grade in Colorectal Cancer Patients

التفاصيل البيبلوغرافية
العنوان: Association of Alpha B-Crystallin Expression with Tumor Differentiation Grade in Colorectal Cancer Patients
المؤلفون: Cristina Pagano, Giovanna Navarra, Patrizia Gazzerro, Mario Vitale, Maria Notarnicola, Maria Gabriella Caruso, Elisabetta Cavalcanti, Raffaele Armentano, Chiara Laezza, Maurizio Bifulco
المصدر: Diagnostics, Vol 11, Iss 5, p 896 (2021)
بيانات النشر: MDPI AG, 2021.
سنة النشر: 2021
المجموعة: LCC:Medicine (General)
مصطلحات موضوعية: Alpha-β-crystallin, colorectal adenocarcinoma, hystological grade, tissues samples, Medicine (General), R5-920
الوصف: Alpha B-crystallin (CRYAB, HSPB5) belongs to the small heat shock protein (HSP) family and is highly expressed in various human cancers, suggesting a crucial role in tumor progression. However, few studies have examined CRYAB expression in colorectal cancer (CRC). In the present study, we investigated the relationship between CRYAB expression and the clinicopathological features of CRC samples. We comparatively analyzed CRYAB protein expression in 111 CRC tissues and normal adjacent colonic tissue, observing that it was significantly lower in CRC tissues than in corresponding non-cancerous tissues. Moreover, immunohistochemical analysis showed a significant correlation between CRYAB expression and high histological grade G3 (p = 0.033). In summary, our results point to its possible application as a prognostic biomarker in CRC patients.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 11050896
2075-4418
Relation: https://www.mdpi.com/2075-4418/11/5/896; https://doaj.org/toc/2075-4418
DOI: 10.3390/diagnostics11050896
URL الوصول: https://doaj.org/article/fe226a0f80614d09acdb31a4071b3ab9
رقم الأكسشن: edsdoj.fe226a0f80614d09acdb31a4071b3ab9
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:11050896
20754418
DOI:10.3390/diagnostics11050896