ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis

التفاصيل البيبلوغرافية
العنوان:	ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis
المؤلفون:	Jacob Paiano, Wei Wu, Shintaro Yamada, Nicholas Sciascia, Elsa Callen, Ana Paola Cotrim, Rajashree A. Deshpande, Yaakov Maman, Amanda Day, Tanya T. Paull, André Nussenzweig
المصدر:	Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
بيانات النشر:	Nature Portfolio, 2020.
سنة النشر:	2020
المجموعة:	LCC:Science
مصطلحات موضوعية:	Science
الوصف:	Recombination requires DNA break formation by SPO11, following which SPO11 is thought to be released. Here, the authors show that meiotic hotspots retain SPO11 through a recombination intermediate dependent on the methyltransferase PRDM9, and that the ATM kinase governs the release of SPO11.
نوع الوثيقة:	article
وصف الملف:	electronic resource
اللغة:	English
تدمد:	2041-1723
Relation:	https://doaj.org/toc/2041-1723
DOI:	10.1038/s41467-020-14654-w
URL الوصول:	https://doaj.org/article/fe2f3dab8f70455daf145802e93451d5
رقم الأكسشن:	edsdoj.fe2f3dab8f70455daf145802e93451d5
قاعدة البيانات:	Directory of Open Access Journals

الوصف
تدمد:	20411723
DOI:	10.1038/s41467-020-14654-w