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Identification of two highly antigenic epitope markers predicting multiple sclerosis in optic neuritis patients

التفاصيل البيبلوغرافية
العنوان: Identification of two highly antigenic epitope markers predicting multiple sclerosis in optic neuritis patients
المؤلفون: Helle Sadam, Arno Pihlak, Mariliis Jaago, Nadežda Pupina, Annika Rähni, Maarja Toots, Antti Vaheri, Janne K. Nieminen, Mika Siuko, Pentti J. Tienari, Kaia Palm
المصدر: EBioMedicine, Vol 64, Iss , Pp 103211- (2021)
بيانات النشر: Elsevier, 2021.
سنة النشر: 2021
المجموعة: LCC:Medicine
LCC:Medicine (General)
مصطلحات موضوعية: Multiple sclerosis, Optic neuritis, Herpesvirus, Epitope, Antigen, CMV, Medicine, Medicine (General), R5-920
الوصف: Background: Optic neuritis (ON) can occur as an isolated episode or will develop to multiple sclerosis (MS) a chronic autoimmune disease. What predicts ON progression to MS remains poorly understood. Methods: We characterised the antibody epitope repertoire in three independent clinical cohorts (discovery (n = 62), validation (n = 20) and external cohort (n = 421)) using mimotope variation analysis (MVA), a next generation phage display technology to identify epitopes that associate with prognosis of ON. Findings: We observed distinct epitope profiles for ON, MS and the controls, whereas epitope repertoires of sera and CSF were highly similar. Two unique and highly immunogenic epitopes A and B were detected in subjects with ON progressing to MS. These epitopes A and B were strongly associated with herpesviral antigens (VCA p18 of Epstein-Barr virus (EBV); gB of Cytomegalovirus (CMV)). ROC addressed 75% of MS subjects with ON onset correctly (at 75% sensitivity and 74.22% specificity) based on the two-epitope biomarker analysis. Interpretation: This is the first report on epitope diagnostics for MS employing the unbiased strategy of MVA for identification of novel immunological features of disease. Funding: The Estonian Ministry of Education, The Estonian Research Council (PRG573, PRG805 and PSG691), H2020-MSCA-RISE-2016 (SZTEST), H2020-NMBP-2017 (PANBIORA), Helsinki University Hospital, Mary and Georg C. Ehrnrooth, Finnish Eye, Sigrid Jusélius and Magnus Ehrnrooth Foundations.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2352-3964
Relation: http://www.sciencedirect.com/science/article/pii/S2352396421000049; https://doaj.org/toc/2352-3964
DOI: 10.1016/j.ebiom.2021.103211
URL الوصول: https://doaj.org/article/fe50e2cc95fa4488b1e0cc58318db9c1
رقم الأكسشن: edsdoj.fe50e2cc95fa4488b1e0cc58318db9c1
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:23523964
DOI:10.1016/j.ebiom.2021.103211