دورية أكاديمية
Meta-analysis identifying gut microbial biomarkers of Qinghai-Tibet Plateau populations and the functionality of microbiota-derived butyrate in high-altitude adaptation
| العنوان: | Meta-analysis identifying gut microbial biomarkers of Qinghai-Tibet Plateau populations and the functionality of microbiota-derived butyrate in high-altitude adaptation |
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| المؤلفون: | Hongwen Zhao, Longjie Sun, Jiali Liu, Bin Shi, Yaopeng Zhang, Ci-Ren Qu-Zong, Tsechoe Dorji, Tieyu Wang, Hongli Yuan, Jinshui Yang |
| المصدر: | Gut Microbes, Vol 16, Iss 1 (2024) |
| بيانات النشر: | Taylor & Francis Group, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Diseases of the digestive system. Gastroenterology |
| مصطلحات موضوعية: | Qinghai-Tibet plateau, gut microbiota biomarker, butyrate, high altitude adaptation, HIF-1α, Diseases of the digestive system. Gastroenterology, RC799-869 |
| الوصف: | ABSTRACTThe extreme environmental conditions of a plateau seriously threaten human health. The relationship between gut microbiota and human health at high altitudes has been extensively investigated. However, no universal gut microbiota biomarkers have been identified in the plateau population, limiting research into gut microbiota and high-altitude adaptation. 668 16s rRNA samples were analyzed using meta-analysis to reduce batch effects and uncover microbiota biomarkers in the plateau population. Furthermore, the robustness of these biomarkers was validated. Mendelian randomization (MR) results indicated that Tibetan gut microbiota may mediate a reduced erythropoietic response. Functional analysis and qPCR revealed that butyrate may be a functional metabolite in high-altitude adaptation. A high-altitude rat model showed that butyrate reduced intestinal damage caused by high altitudes. According to cell experiments, butyrate may downregulate hypoxia-inducible factor-1α (HIF-1α) expression and blunt cellular responses to hypoxic stress. Our research found universally applicable biomarkers and investigated their potential roles in promoting human health at high altitudes. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 19490976 1949-0984 1949-0976 |
| Relation: | https://doaj.org/toc/1949-0976; https://doaj.org/toc/1949-0984 |
| DOI: | 10.1080/19490976.2024.2350151 |
| URL الوصول: | https://doaj.org/article/adfe5a8c92444e93b8daf5af3941e5db |
| رقم الأكسشن: | edsdoj.fe5a8c92444e93b8daf5af3941e5db |
| قاعدة البيانات: | Directory of Open Access Journals |
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Full Text Finder | تدمد: | 19490976 19490984 |
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| DOI: | 10.1080/19490976.2024.2350151 |