دورية أكاديمية
Production, biodistribution, and dosimetry of 47Sc-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethylene phosphonic acid as a bone-seeking radiopharmaceutical
| العنوان: | Production, biodistribution, and dosimetry of 47Sc-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethylene phosphonic acid as a bone-seeking radiopharmaceutical |
|---|---|
| المؤلفون: | Fatemeh Fathi, Leila Moghaddam-Banaem, Mojtaba Shamsaei, Ali Samani, Mohammad G Maragheh |
| المصدر: | Journal of Medical Physics, Vol 40, Iss 3, Pp 156-164 (2015) |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2015. |
| سنة النشر: | 2015 |
| المجموعة: | LCC:Medical physics. Medical radiology. Nuclear medicine |
| مصطلحات موضوعية: | 47/46Sc-1, 10-tetraazacyclododecane-1, 10-tetramethylene phosphonic acid, biodistribution, dosimetry, radiopharmaceuticals, Medical physics. Medical radiology. Nuclear medicine, R895-920 |
| الوصف: | In this study 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethylene phosphonic acid (DOTMP) was used as the polyaminophosphonic acid carrier ligand and the therapeutic potential of the bone seeking radiopharmaceutical 47Sc-DOTMP was assessed by measuring its dosage–dependent skeletal uptake and then the absorbed radiation dose of human organs was estimated. Because of limited availability of 47Sc we performed some preliminary studies using 46Sc. 46Sc was produced with a specific activity of 116.58 MBq/mg (3.15 mCi/mg) and radionuclide purity of 98%. 46Sc-DOTMP was prepared and an activity of 1.258 MBq (34 μCi) at a chelant-to-metal ratio of 60:1 was administered to five groups of mice with each group containing 3 mice that were euthanized at 4, 24, 48, 96 and 192 h post administration. The heart, lungs, liver, spleen, kidneys, intestine, skin, muscle, and a femur were excised, weighed, and counted. The data were analyzed to determine skeletal uptake and source organ residence times and cumulated activities for 47Sc-DOTMP. 46Sc-DOTMP complex was prepared in radiochemical purity about 93%. In vitro stability of complex was evaluated at room temperature for 48 h. Biodistribution studies of complex in mice were studied for 7 days. The data were analyzed to estimate skeletal uptake and absorbed radiation dose of human organs using biodistribution data from mice. By considering the results, 47Sc-DOTMP is a possible therapeutic agent for using in palliation of bone pain due to metastatic skeletal lesions from several types of primary cancers in prostate, breast, etc. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0971-6203 1998-3913 |
| Relation: | http://www.jmp.org.in/article.asp?issn=0971-6203;year=2015;volume=40;issue=3;spage=156;epage=164;aulast=Fathi; https://doaj.org/toc/0971-6203; https://doaj.org/toc/1998-3913 |
| DOI: | 10.4103/0971-6203.165078 |
| URL الوصول: | https://doaj.org/article/fe5bf21f52874d508291fb86c2a22b65 |
| رقم الأكسشن: | edsdoj.fe5bf21f52874d508291fb86c2a22b65 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 09716203 19983913 |
|---|---|
| DOI: | 10.4103/0971-6203.165078 |