دورية أكاديمية
Modern Possibilities of Using Acotiamide in the Treatment of Functional Dyspepsia
| العنوان: | Modern Possibilities of Using Acotiamide in the Treatment of Functional Dyspepsia |
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| المؤلفون: | A. A. Sheptulin, Yu. S. Rabotyagova |
| المصدر: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии, Vol 34, Iss 1, Pp 70-75 (2024) |
| بيانات النشر: | Gastro LLC, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Diseases of the digestive system. Gastroenterology |
| مصطلحات موضوعية: | functional dyspepsia, prokinetics, acotiamide, Diseases of the digestive system. Gastroenterology, RC799-869 |
| الوصف: | Aim: to evaluate the efficacy and safety of the new prokinetic drug acotiamide in the treatment of functional dyspepsia.Key findings. Acotiamide is an antagonist of inhibitory muscarinic receptors of type 1 and 2 and a reversible inhibitor of acetylcholinesterase activity. In patients with functional dyspepsia acotiamide normalizes the accommodation of the fundal part of the stomach and accelerates delayed gastric emptying. The conducted studies have confirmed the higher efficacy of acotiamide compared to placebo in reducing the severity of such symptoms of functional dyspepsia as a feeling of epigastric postprandial fullness and bloating, early satiation. The advantage of acotiamide in comparison to other prokinetics (in particular, metoclopramide and domperidone) is the high safety of use and the absence of influence on the duration of the Q-T interval.Conclusion. The high efficacy and safety of the application makes it advisable to use acotiamide in the treatment of patients with functional dyspepsia. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Russian |
| تدمد: | 1382-4376 2658-6673 |
| Relation: | https://www.gastro-j.ru/jour/article/view/845; https://doaj.org/toc/1382-4376; https://doaj.org/toc/2658-6673 |
| DOI: | 10.22416/1382-4376-2024-34-1-70-75 |
| URL الوصول: | https://doaj.org/article/afe7555cbae141a3bdc50c2bd33b1a58 |
| رقم الأكسشن: | edsdoj.fe7555cbae141a3bdc50c2bd33b1a58 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 13824376 26586673 |
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| DOI: | 10.22416/1382-4376-2024-34-1-70-75 |