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HapX-mediated adaption to iron starvation is crucial for virulence of Aspergillus fumigatus.

التفاصيل البيبلوغرافية
العنوان: HapX-mediated adaption to iron starvation is crucial for virulence of Aspergillus fumigatus.
المؤلفون: Markus Schrettl, Nicola Beckmann, John Varga, Thorsten Heinekamp, Ilse D Jacobsen, Christoph Jöchl, Tarek A Moussa, Shaohua Wang, Fabio Gsaller, Michael Blatzer, Ernst R Werner, William C Niermann, Axel A Brakhage, Hubertus Haas
المصدر: PLoS Pathogens, Vol 6, Iss 9, p e1001124 (2010)
بيانات النشر: Public Library of Science (PLoS), 2010.
سنة النشر: 2010
المجموعة: LCC:Immunologic diseases. Allergy
LCC:Biology (General)
مصطلحات موضوعية: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5
الوصف: Iron is essential for a wide range of cellular processes. Here we show that the bZIP-type regulator HapX is indispensable for the transcriptional remodeling required for adaption to iron starvation in the opportunistic fungal pathogen Aspergillus fumigatus. HapX represses iron-dependent and mitochondrial-localized activities including respiration, TCA cycle, amino acid metabolism, iron-sulfur-cluster and heme biosynthesis. In agreement with the impact on mitochondrial metabolism, HapX-deficiency decreases resistance to tetracycline and increases mitochondrial DNA content. Pathways positively affected by HapX include production of the ribotoxin AspF1 and siderophores, which are known virulence determinants. Iron starvation causes a massive remodeling of the amino acid pool and HapX is essential for the coordination of the production of siderophores and their precursor ornithine. Consistent with HapX-function being limited to iron depleted conditions and A. fumigatus facing iron starvation in the host, HapX-deficiency causes significant attenuation of virulence in a murine model of aspergillosis. Taken together, this study demonstrates that HapX-dependent adaption to conditions of iron starvation is crucial for virulence of A. fumigatus.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1553-7366
1553-7374
Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20941352/?tool=EBI; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374
DOI: 10.1371/journal.ppat.1001124
URL الوصول: https://doaj.org/article/feac8ba4ae864815876ffffab965291f
رقم الأكسشن: edsdoj.feac8ba4ae864815876ffffab965291f
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:15537366
15537374
DOI:10.1371/journal.ppat.1001124