دورية أكاديمية
Intra-specific regulatory variation in Drosophila pseudoobscura.
| العنوان: | Intra-specific regulatory variation in Drosophila pseudoobscura. |
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| المؤلفون: | Anton Suvorov, Viola Nolte, Ram Vinay Pandey, Susanne U Franssen, Andreas Futschik, Christian Schlötterer |
| المصدر: | PLoS ONE, Vol 8, Iss 12, p e83547 (2013) |
| بيانات النشر: | Public Library of Science (PLoS), 2013. |
| سنة النشر: | 2013 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | It is generally accepted that gene regulation serves an important role in determining the phenotype. To shed light on the evolutionary forces operating on gene regulation, previous studies mainly focused on the expression differences between species and their inter-specific hybrids. Here, we use RNA-Seq to study the intra-specific distribution of cis- and trans-regulatory variation in Drosophila pseudoobscura. Consistent with previous results, we find almost twice as many genes (26%) with significant trans-effects than genes with significant cis-effects (18%). While this result supports the previous suggestion of a larger mutational target of trans-effects, we also show that trans-effects may be subjected to purifying selection. Our results underline the importance of intra-specific analyses for the understanding of the evolution of gene expression. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1932-6203 |
| Relation: | http://europepmc.org/articles/PMC3873948?pdf=render; https://doaj.org/toc/1932-6203 |
| DOI: | 10.1371/journal.pone.0083547 |
| URL الوصول: | https://doaj.org/article/febcd524147c410983ef88e1184c32e6 |
| رقم الأكسشن: | edsdoj.febcd524147c410983ef88e1184c32e6 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0083547 |