دورية أكاديمية
A comprehensive analysis of spermatozoal RNA elements in idiopathic infertile males undergoing fertility treatment
| العنوان: | A comprehensive analysis of spermatozoal RNA elements in idiopathic infertile males undergoing fertility treatment |
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| المؤلفون: | Matthew Hamilton, Stewart Russell, Grace M. Swanson, Stephen A. Krawetz, Karen Menezes, Sergey I. Moskovtsev, Clifford Librach |
| المصدر: | Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024) |
| بيانات النشر: | Nature Portfolio, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Abstract Current approaches to diagnosing male infertility inadequately assess the complexity of the male gamete. Beyond the paternal haploid genome, spermatozoa also deliver coding and non-coding RNAs to the oocyte. While sperm-borne RNAs have demonstrated potential involvement in embryo development, the underlying mechanisms remain unclear. In this study, 47 sperm samples from normozoospermic males undergoing fertility treatment using donor oocytes were sequenced and analyzed to evaluate associations between sperm RNA elements (exon-sized sequences) and blastocyst progression. A total of 366 RNA elements (REs) were significantly associated with blastocyst rate (padj |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-024-60586-6 |
| URL الوصول: | https://doaj.org/article/fec812a155d84fc08d088ac99df539a2 |
| رقم الأكسشن: | edsdoj.fec812a155d84fc08d088ac99df539a2 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-024-60586-6 |