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The Zinc-Schiff Base-Novicidin Complex as a Potential Prostate Cancer Therapy.

التفاصيل البيبلوغرافية
العنوان: The Zinc-Schiff Base-Novicidin Complex as a Potential Prostate Cancer Therapy.
المؤلفون: Vedran Milosavljevic, Yazan Haddad, Miguel Angel Merlos Rodrigo, Amitava Moulick, Hana Polanska, David Hynek, Zbynek Heger, Pavel Kopel, Vojtech Adam
المصدر: PLoS ONE, Vol 11, Iss 10, p e0163983 (2016)
بيانات النشر: Public Library of Science (PLoS), 2016.
سنة النشر: 2016
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Prostate cancer cells control energy metabolism by chelating intracellular zinc. Thus, zinc delivery has been a popular therapeutic approach for prostate cancer. Here, we propose the use of the membrane-penetrating peptide Novicidin connected to zinc-Schiff base as a carrier vehicle for the delivery of zinc to prostate cells. Mass spectrometry, electrochemistry and spectrophotometry confirmed the formation/stability of this complex and provided insight regarding the availability of zinc for complex interactions. This delivery system showed minor toxicity in normal PNT1A cells and high potency towards PC3 tumor cells. The complex preferentially penetrated PC3 tumor cells in contrast to confinement to the membranes of PNT1A. Furthermore, zinc uptake was confirmed in both cell lines. Molecular analysis was used to confirm the activation of zinc stress (e.g., ZnT-1) and apoptosis (e.g., CASP-1). Our results strongly suggest that the zinc-Schiff base-Novicidin complex has great potential as a novel anticancer drug.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC5058503?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0163983
URL الوصول: https://doaj.org/article/ff06f133ca46455982f5b4c613ce4caf
رقم الأكسشن: edsdoj.ff06f133ca46455982f5b4c613ce4caf
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0163983