دورية أكاديمية
Responsiveness to anti-PD-1 and anti-CTLA-4 immune checkpoint blockade in SB28 and GL261 mouse glioma models
العنوان: | Responsiveness to anti-PD-1 and anti-CTLA-4 immune checkpoint blockade in SB28 and GL261 mouse glioma models |
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المؤلفون: | Vassilis Genoud, Eliana Marinari, Sergey I Nikolaev, John C. Castle, Valesca Bukur, Pierre-Yves Dietrich, Hideho Okada, Paul R. Walker |
المصدر: | OncoImmunology, Vol 7, Iss 12 (2018) |
بيانات النشر: | Taylor & Francis Group, 2018. |
سنة النشر: | 2018 |
المجموعة: | LCC:Immunologic diseases. Allergy LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
مصطلحات موضوعية: | immune checkpoint blockade, glioblastoma, gl261, sb28, mutational load, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
الوصف: | Immune checkpoint blockade (ICB) is currently evaluated in patients with glioblastoma (GBM), based on encouraging clinical data in other cancers, and results from studies with the methylcholanthrene-induced GL261 mouse glioma. In this paper, we describe a novel model faithfully recapitulating some key human GBM characteristics, including low mutational load, a factor reported as a prognostic indicator of ICB response. Consistent with this observation, SB28 is completely resistant to ICB, contrasting with treatment sensitivity of the more highly mutated GL261. Moreover, SB28 shows features of a poorly immunogenic tumor, with low MHC-I expression and modest CD8+ T-cell infiltration, suggesting that it may present similar challenges for immunotherapy as human GBM. Based on these key features for immune reactivity, SB28 may represent a treatment-resistant malignancy likely to mirror responses of many human tumors. We therefore propose that SB28 is a particularly suitable model for optimization of GBM immunotherapy. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 2162-402X 2162402X |
Relation: | https://doaj.org/toc/2162-402X |
DOI: | 10.1080/2162402X.2018.1501137 |
URL الوصول: | https://doaj.org/article/ff0f1c46268643f284c500382f723d44 |
رقم الأكسشن: | edsdoj.ff0f1c46268643f284c500382f723d44 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 2162402X |
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DOI: | 10.1080/2162402X.2018.1501137 |