دورية أكاديمية
Association between rs267196 and rs267201 of BMP6 gene and osteonecrosis among Sickle Cell Aneamia patients
| العنوان: | Association between rs267196 and rs267201 of BMP6 gene and osteonecrosis among Sickle Cell Aneamia patients |
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| المؤلفون: | Leila Chaouch, Miniar Kalai, Manel Ben Jbara, Arij Ben Chaabene, Imen Darragi, Dorra Chaouachi, Fethi Mallouli, Raouf Hafsia, Abderraouf Ghanem, Salem Abbes |
| المصدر: | Biomedical Papers, Vol 159, Iss 1, Pp 145-149 (2015) |
| بيانات النشر: | Palacký University Olomouc, Faculty of Medicine and Dentistry, 2015. |
| سنة النشر: | 2015 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | sickle cell anemia, bmp6 polymorphisms, osteonecrosis, Medicine |
| الوصف: | Aims: The skeletal manifestations of sickle cell disease are the result of changes in bone and bone marrow caused by chronic tissue hypoxia that is exacerbated by episodic occlusion of the microcirculation by the abnormal sickle cells. Furthermore, the occurrence of osteonecrosis is under the control of some modifier gene. BMP6 (Bone morphogenetic protein) has been reported as associated with osteonecrosis in sickle cell anemia (SCA). Herein, we intend to study the impact of rs267196, rs267201, rs408505 and rs449853 of BMP6 gene in the occurrence of osteonecrosis among sickle cell patients in Tunisia. Methods: Our study involved 100 SCA patients among whom 19 have osteonecrosis of the head of the femur. The latter polymorphisms of BMP6 gene were analyzed for all subjects by PCR/sequencing. To test for trait association with the candidate SNPs, genotype and allele frequencies between cases (osteonecrosis group) and controls (non-osteonecrosis group) were compared using Pearson's chi_square test with a significance threshold of P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1213-8118 1804-7521 |
| Relation: | https://biomed.papers.upol.cz/artkey/bio-201501-0023_Association_between_rs267196_and_rs267201_of_BMP6_gene_and_osteonecrosis_among_Sickle_Cell_Aneamia_patients.php; https://doaj.org/toc/1213-8118; https://doaj.org/toc/1804-7521 |
| DOI: | 10.5507/bp.2013.080 |
| URL الوصول: | https://doaj.org/article/ff6c76f4151f4f91bc425bf5c7cf1453 |
| رقم الأكسشن: | edsdoj.ff6c76f4151f4f91bc425bf5c7cf1453 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 12138118 18047521 |
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| DOI: | 10.5507/bp.2013.080 |