دورية أكاديمية
Unraveling the superiority of (−)‐gallocatechin gallate to (−)‐epigallocatechin‐3‐gallate in protection of diabetic nephropathy of db/db mice
| العنوان: | Unraveling the superiority of (−)‐gallocatechin gallate to (−)‐epigallocatechin‐3‐gallate in protection of diabetic nephropathy of db/db mice |
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| المؤلفون: | Xin Xiao, Ling Feng, Huijun Cheng, Huifang Ge, Yijun Wang, Xiaochun Wan, Daxiang Li, Zhongwen Xie |
| المصدر: | Food Frontiers, Vol 5, Iss 2, Pp 771-788 (2024) |
| بيانات النشر: | Wiley, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Nutrition. Foods and food supply LCC:Food processing and manufacture |
| مصطلحات موضوعية: | comparison, db/db, diabetic nephropathy, EGCG, GCG, transcriptome analysis, Nutrition. Foods and food supply, TX341-641, Food processing and manufacture, TP368-456 |
| الوصف: | Abstract GCG ((−)‐gallocatechin gallate) and EGCG ((−)‐epigallocatechin‐3‐gallate) are main biologically active polyphenolic compounds in tea leaves, and EGCG has been studied for its potential effects on alleviating diabetic nephropathy (DN). Previous studies showed that GCG exhibited better hypoglycemic and antioxidant efficacy than EGCG. However, the efficacy and molecular mechanisms of GCG in the protection of DN are unknown. In this study, db/db mice were administered with EGCG or GCG orally for 20 weeks to comparatively investigate their effects on DN. These results revealed that GCG was significantly more effective than EGCG in decreasing water intake and urine excretion, reducing fasting blood glucose levels and systolic blood pressure, improving mesenteric artery contractility, enhancing the right renal hemodynamics, and improving key renal function markers. Through transcriptome analysis, S100A8/S100A9, two regulators of interstitial fibrosis, were identified and found to be more sensitive to GCG intervention, which was further confirmed by mRNA and protein expression data. In addition, the molecular docking analysis results demonstrated that GCG displayed a superior binding affinity toward S100A8/S100A9 in comparison to EGCG. Overall, our study found that GCG holds significant potential for the treatment of DN and outperforms EGCG in terms of efficacy. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2643-8429 |
| Relation: | https://doaj.org/toc/2643-8429 |
| DOI: | 10.1002/fft2.356 |
| URL الوصول: | https://doaj.org/article/ff6ccb96d659472abbfa9a65e7627cce |
| رقم الأكسشن: | edsdoj.ff6ccb96d659472abbfa9a65e7627cce |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 26438429 |
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| DOI: | 10.1002/fft2.356 |