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Innovation of heterochromatin functions drives rapid evolution of essential ZAD-ZNF genes in Drosophila

التفاصيل البيبلوغرافية
العنوان: Innovation of heterochromatin functions drives rapid evolution of essential ZAD-ZNF genes in Drosophila
المؤلفون: Bhavatharini Kasinathan, Serafin U Colmenares III, Hannah McConnell, Janet M Young, Gary H Karpen, Harmit S Malik
المصدر: eLife, Vol 9 (2020)
بيانات النشر: eLife Sciences Publications Ltd, 2020.
سنة النشر: 2020
المجموعة: LCC:Medicine
LCC:Science
LCC:Biology (General)
مصطلحات موضوعية: heterochromatin, positive selection, gene turnover, krab-zinc finger, gene essentiality, chromatin, Medicine, Science, Biology (General), QH301-705.5
الوصف: Contrary to dogma, evolutionarily young and dynamic genes can encode essential functions. We find that evolutionarily dynamic ZAD-ZNF genes, which encode the most abundant class of insect transcription factors, are more likely to encode essential functions in Drosophila melanogaster than ancient, conserved ZAD-ZNF genes. We focus on the Nicknack ZAD-ZNF gene, which is evolutionarily young, poorly retained in Drosophila species, and evolves under strong positive selection. Yet we find that it is necessary for larval development in D. melanogaster. We show that Nicknack encodes a heterochromatin-localizing protein like its paralog Oddjob, also an evolutionarily dynamic yet essential ZAD-ZNF gene. We find that the divergent D. simulans Nicknack protein can still localize to D. melanogaster heterochromatin and rescue viability of female but not male Nicknack-null D. melanogaster. Our findings suggest that innovation for rapidly changing heterochromatin functions might generally explain the essentiality of many evolutionarily dynamic ZAD-ZNF genes in insects.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2050-084X
Relation: https://elifesciences.org/articles/63368; https://doaj.org/toc/2050-084X
DOI: 10.7554/eLife.63368
URL الوصول: https://doaj.org/article/ff87ca4533974434b7eb2d974ade17fe
رقم الأكسشن: edsdoj.ff87ca4533974434b7eb2d974ade17fe
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:2050084X
DOI:10.7554/eLife.63368