دورية أكاديمية
Determining the Significant Prognostic Factors for the Recurrence of Pediatric Acute Lymphoblastic Leukemia Using a Competing Risks Approach
| العنوان: | Determining the Significant Prognostic Factors for the Recurrence of Pediatric Acute Lymphoblastic Leukemia Using a Competing Risks Approach |
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| المؤلفون: | Anahita Saeedi, Ahmadreza Baghestani, Aliakbar Khadem Maboudi, Hamid Farhangi |
| المصدر: | Iranian Journal of Medical Sciences, Vol 45, Iss 4, Pp 304-310 (2020) |
| بيانات النشر: | Shiraz University of Medical Sciences, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Medicine (General) |
| مصطلحات موضوعية: | survival analyses, lymphoblastic leukemia, acute, childhood, competing risks, Medicine (General), R5-920 |
| الوصف: | Acute lymphoblastic leukemia (ALL) is the most common cause of cancer-related fatality among children. This study aimed to identify the significant prognostic factors for the incidence of pediatric ALL. This retrospective study, conducted from 2007 to 2016 in the Iranian city of Mashhad, enrolled 417 patients with ALL. The diagnosis was confirmed by Giemsa staining of bone marrow smears. The first recurrence was regarded as the event of interest and non-relapse mortality as the competing event through a three-parameter Gompertz model. The level of statistical significance for univariate and multivariate analyses was set at 0.2 and 0.05, respectively. The first recurrence occurred in 44 (10.6%) survivors. Disease-free survival and 5-year overall survival rates were 85.9% and 74%, correspondingly. The five-year incidence rate for the first recurrence was 11.5% in the presence of non-relapse mortality. Briefly, the characteristics of the Gompertz model conferred more effective prognostic factors. Age above 10 years (P=0.010), involvement of the central nervous system (P=0.050), a high white blood cell count (P=0.020), and tumor lysis syndrome (P=0.010) were the significant prognostic factors for the recurrence and mortality of ALL. Accordingly, careful monitoring in the administration of treatment protocols is suggested to reduce the risk of recurrence and death in these patients. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0253-0716 1735-3688 |
| Relation: | https://ijms.sums.ac.ir/article_46692_ad22e51b8cfbd094c46e04980f8bda3a.pdf; https://doaj.org/toc/0253-0716; https://doaj.org/toc/1735-3688 |
| DOI: | 10.30476/ijms.2020.83123.1188 |
| URL الوصول: | https://doaj.org/article/ffde3ac7f76742809c1fb72fd8806ea8 |
| رقم الأكسشن: | edsdoj.ffde3ac7f76742809c1fb72fd8806ea8 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 02530716 17353688 |
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| DOI: | 10.30476/ijms.2020.83123.1188 |