كتاب
أعرض في EDS

Clinical Pharmacology During Pregnancy

التفاصيل البيبلوغرافية
العنوان: Clinical Pharmacology During Pregnancy
المؤلفون: Mattison, Donald.
بيانات النشر: Burlington : Elsevier Science, 2013.
سنة النشر: 2013
وصف مادي: 1 online resource (495 p.)
مصطلحات موضوعية: Pregnancy., Newborn infants -- Physiology., Fetus -- Physiology., Obstetrical pharmacology., Pregnancy -- drug effects., Drug Therapy., Infant, Newborn -- physiology., Pregnancy -- physiology., MEDICAL -- Gynecology & Obstetrics., Electronic books.
الوصف: Clinical Pharmacology During Pregnancy is written for clinicians, physicians, midwives, nurses, pharmacists and other medical professionals directly involved in the care of women during pregnancy. This book focuses on the impact of pregnancy on drug disposition and also includes coverage of treatments for diseases of specific body systems, as well as essential content on dosing and efficacy. Written in a clear and practical manner, this reference provides easily accessible information and clinical guidance on how best to treat women with medications during pregnancy.
ملاحظة حول المحتويات: Front Cover; Clinical Pharmacology During Pregnancy; Copyright; Contents; Contributors; 1 -- Introduction; References; 2 -- Physiologic Changes During Pregnancy; 2.1Physiologic changes during pregnancy; 2.2Cardiovascular system; 2.3Respiratory system; 2.4Renal system; 2.5Gastrointestinal system; 2.6Hematologic and coagulation systems; 2.7Endocrine system; 2.8Summary; References; 3 -- Impact of Pregnancy on Maternal Pharmacokinetics of Medications; 3.1Introduction; 3.2Effects of pregnancy on pharmacokinetic parameters; 3.3Summary; References; 4 -- Medications and the Breastfeeding Mother.
4.1Medication use by the breastfeeding mother4.2Clinical pharmacology of drug transfer into breast milk; 4.3During delivery; 4.4General anesthesia; 4.5Epidural anesthesia; 4.6Galactogogues; 4.7Immediate postpartum period; 4.8Pain; 4.9Methadone; 4.10Resumption of pre-pregnancy medications; 4.11Psycho- and neurotropic drugs; 4.12Drugs not to give to the nursing mother postpartum; 4.13Oral contraceptives (OCPs); 4.14Summary; 4.15Where to find information; References; 5 -- Fetal Drug Therapy; 5.1Introduction; 5.2Indications for fetal therapy; 5.3Strategies to achieve fetal drug therapy.
5.4Special considerationsAcknowledgments; References; 6 -- Treating the Placenta: an Evolving Therapeutic Concept; 6.1Introduction; 6.2The placenta as the therapeutic target: the past; 6.3The placenta: therapeutic targets; 6.4The placenta as a therapeutic target today; 6.5The placenta as a therapeutic target in the future; Conclusions; References; 7 -- What is Sufficient Evidence to Justify a Multicenter Phase 3 Randomized Controlled Trial in Obstetrics?; 7.1Introduction; 7.2Evidence, equipoise, and the ethical considerations in deciding whether to conduct a trial.
7.3Why are failure rates so high for pregnancy drug trials compared to other therapeutic areas?7.4Role of phase 2 trials; 7.5How to improve success rates; 7.6Learning from experience -- the example of antioxidants and preeclampsia; Conclusions and recommendations; References; 8 -- Ethics of Clinical Pharmacology Research in Pregnancy; References; Questions for further discussion; 9 -- Pharmacogenomics in Pregnancy; 9.1Pharmacogenomics; 9.2Genetics and polymorphisms; 9.3Genes that influence pharmacokinetic variability; 9.4The current state of pharmacogenetic testing.
9.5Potential therapeutic areas for pharmacogenomics in pregnancy9.6Study designs and approaches to pharmacogenetics trials; References; 10 -- Analgesics and Anti-Inflammatory, General and Local Anesthetics and Muscle Relaxants; 10.1Introduction; 10.2General anesthesia; 10.3Inhalational anesthetics; 10.4Intravenous anesthetics; 10.5Neuromuscular blocking agents; 10.6Regional anesthesia; 10.7Summary; References; 11 -- The Management of Asthma During Pregnancy; 11.1Introduction; 11.2Effect of pregnancy on the course of asthma; 11.3Effect of asthma on pregnancy; 11.4Asthma management.
Original Identifier: ocn818866951
نوع الوثيقة: Book
اللغة: English
ردمك: 978-0-12-386008-8
978-0-12-386007-1
0-12-386008-3
0-12-386007-5
حقوق: This record is part of the Harvard Library Bibliographic Dataset, which is provided by the Harvard Library under its Bibliographic Dataset Use Terms and includes data made available by, among others, OCLC Online Computer Library Center, Inc. and the Library of Congress.
ملاحظات: 11.5Pharmacologic therapy.
رقم الأكسشن: edshlc.013625313.X
قاعدة البيانات: Harvard Library Bibliographic Dataset
الوصف
ردمك:9780123860088
9780123860071
0123860083
0123860075