دورية أكاديمية
Non-redundant Requirement for CXCR3 Signaling during Tumoricidal T Cell Trafficking across Tumor Vascular Checkpoints
| العنوان: | Non-redundant Requirement for CXCR3 Signaling during Tumoricidal T Cell Trafficking across Tumor Vascular Checkpoints |
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| المؤلفون: | Mikucki, ME, Fisher, DT, Matsuzaki, J, Skitzki, JJ, Gaulin, NB, Muhitch, JB, Ku, AW, Frelinger, JG, Odunsi, K, Gajewski, TF, Luster, AD, Evans, SS |
| المصدر: | Mikucki, M., D. Fisher, J. Matsuzaki, J. Skitzki, N. Gaulin, J. Muhitch, A. Ku, et al. 2015. “Non-redundant Requirement for CXCR3 Signaling during Tumoricidal T Cell Trafficking across Tumor Vascular Checkpoints.” Nature communications 6 (1): 7458. doi:10.1038/ncomms8458. http://dx.doi.org/10.1038/ncomms8458. |
| سنة النشر: | 2015 |
| المجموعة: | HMS Scholarly Articles |
| الوصف: | T cell trafficking at vascular sites has emerged as a key step in antitumor immunity. Chemokines are credited with guiding the multistep recruitment of CD8+ T cells across tumor vessels. However, the multiplicity of chemokines within tumors has obscured the contributions of individual chemokine receptor/chemokine pairs to this process. Moreover, recent studies have challenged whether T cells require chemokine receptor signaling at effector sites. Here, we investigate the hierarchy of chemokine receptor requirements during T cell trafficking to murine and human melanoma. These studies reveal a non-redundant role for GαI-coupled CXCR3 in stabilizing intravascular adhesion and extravasation of adoptively transferred CD8+ effectors that is indispensable for therapeutic efficacy. In contrast, functional CCR2 and CCR5 on CD8+ effectors fail to support trafficking despite the presence of intratumoral cognate chemokines. Taken together, these studies identify CXCR3-mediated trafficking at the tumor vascular interface as a critical checkpoint to effective T cell-based cancer immunotherapy. |
| نوع الوثيقة: | Journal Article |
| اللغة: | English |
| تدمد: | 2041-1723 |
| Relation: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605273/pdf/; Nature communications |
| DOI: | 10.1038/ncomms8458 |
| URL الوصول: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:23993537 |
| حقوق: | open URL: http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA |
| رقم الأكسشن: | edshld.1.23993537 |
| قاعدة البيانات: | Digital Access to Scholarship at Harvard (DASH) |
Full Text Finder | تدمد: | 20411723 |
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| DOI: | 10.1038/ncomms8458 |