دورية أكاديمية
Prostate Cancer Susceptibility Polymorphism rs2660753 Is Not Associated with Invasive Ovarian Cancer
| العنوان: | Prostate Cancer Susceptibility Polymorphism rs2660753 Is Not Associated with Invasive Ovarian Cancer |
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| المؤلفون: | Amankwah, E. K., Kelemen, L. E., Wang, Q., Song, H., Chenevix-Trench, G., Beesley, J., Webb, P. M., Pearce, C. L., Wu, A. H., Pike, M. C., Stram, D. O., Chang-Claude, J., Wang-Gohrke, S., Ness, R. B., Goode, E. L., Cunningham, J. M., Fridley, B. L., Vierkant, R. A., Tworoger, Shelley Slate, Whittemore, A. S., McGuire, V., Sieh, W., Gayther, S. A., Gentry-Maharaj, A., Menon, U., Ramus, S. J., Rossing, M. A., Doherty, J. A., Goodman, M. T., Carney, M. E., Lurie, G., Wilkens, L. R., Kruger Kjaer, S., Hogdall, E., Cramer, Daniel William, Terry, Kathryn Lynne, Garcia-Closas, M., Yang, H., Lissowska, J., Anton-Culver, H., Ziogas, A., Schildkraut, J. M., Berchuck, A., Pharoah, P. D. P. |
| المصدر: | Amankwah, E. K., L. E. Kelemen, Q. Wang, H. Song, G. Chenevix-Trench, J. Beesley, P. M. Webb, et al. 2011. “Prostate Cancer Susceptibility Polymorphism Rs2660753 Is Not Associated with Invasive Ovarian Cancer.” Cancer Epidemiology Biomarkers & Prevention 20 (5) (March 17): 1028–1031. doi:10.1158/1055-9965.epi-11-0053. |
| بيانات النشر: | American Association for Cancer Research (AACR), 2011. |
| سنة النشر: | 2011 |
| المجموعة: | HMS Scholarly Articles |
| مصطلحات موضوعية: | chromosome 3p, SNP, ovarian cancer, risk factors |
| الوصف: | Background We previously reported an association between rs2660753, a prostate cancer susceptibility polymorphism, and invasive epithelial ovarian cancer (EOC) [odds ratio (OR)=1.2, 95% confidence interval (CI)=1.0-1.4, Ptrend=0.01] that showed a stronger association with the serous histological subtype (OR=1.3, 95% CI=1.1-1.5, Ptrend=0.003). Methods We sought to replicate this association in 12 other studies comprising 4,482 cases and 6,894 controls of white non-Hispanic ancestry in the Ovarian Cancer Association Consortium. Results No evidence for an association with all cancers or serous cancers was observed in a combined analysis of data from the replication studies (all: OR=1.0, 95% CI=0.9-1.1, Ptrend=0.61; serous: OR=1.0, 95% CI=0.9-1.1, Ptrend=0.85) or from the combined analysis of discovery and replication studies (all: OR=1.0, 95% CI=1.0-1.1, Ptrend= 0.28; serous: OR=1.1, 95% CI=1.0-1.2, Ptrend=0.11). There was no evidence for statistical heterogeneity in ORs across the studies. Conclusions Although rs2660753 is a strong a prostate cancer susceptibility polymorphism, the association with another hormonally related cancer, invasive EOC, is not supported by this replication study. Impact Our findings, based on a larger sample size, emphasize the importance of replicating potentially promising genetic risk associations. |
| نوع الوثيقة: | Journal Article |
| اللغة: | English |
| تدمد: | 1055-9965 |
| Relation: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176661/; Cancer Epidemiology Biomarkers & Prevention |
| DOI: | 10.1158/1055-9965.EPI-11-0053 |
| URL الوصول: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:27336533 |
| حقوق: | open URL: http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA |
| رقم الأكسشن: | edshld.1.27336533 |
| قاعدة البيانات: | Digital Access to Scholarship at Harvard (DASH) |
| تدمد: | 10559965 |
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| DOI: | 10.1158/1055-9965.EPI-11-0053 |