دورية أكاديمية
Identification of Altered Metabolomic Profiles Following a Panchakarma-based Ayurvedic Intervention in Healthy Subjects: The Self-Directed Biological Transformation Initiative (SBTI)
| العنوان: | Identification of Altered Metabolomic Profiles Following a Panchakarma-based Ayurvedic Intervention in Healthy Subjects: The Self-Directed Biological Transformation Initiative (SBTI) |
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| المؤلفون: | Peterson, Christine Tara, Lucas, Joseph, John-Williams, Lisa St., Thompson, J. Will, Moseley, M. Arthur, Patel, Sheila, Peterson, Scott N., Porter, Valencia, Schadt, Eric E., Mills, Paul J., Tanzi, Rudolph E., Doraiswamy, P. Murali, Chopra, Deepak |
| المصدر: | Peterson, C. T., J. Lucas, L. S. John-Williams, J. W. Thompson, M. A. Moseley, S. Patel, S. N. Peterson, et al. 2016. “Identification of Altered Metabolomic Profiles Following a Panchakarma-based Ayurvedic Intervention in Healthy Subjects: The Self-Directed Biological Transformation Initiative (SBTI).” Scientific Reports 6 (1): 32609. doi:10.1038/srep32609. http://dx.doi.org/10.1038/srep32609. |
| بيانات النشر: | Nature Publishing Group, 2016. |
| سنة النشر: | 2016 |
| المجموعة: | HMS Scholarly Articles |
| الوصف: | The effects of integrative medicine practices such as meditation and Ayurveda on human physiology are not fully understood. The aim of this study was to identify altered metabolomic profiles following an Ayurveda-based intervention. In the experimental group, 65 healthy male and female subjects participated in a 6-day Panchakarma-based Ayurvedic intervention which included herbs, vegetarian diet, meditation, yoga, and massage. A set of 12 plasma phosphatidylcholines decreased (adjusted p < 0.01) post-intervention in the experimental (n = 65) compared to control group (n = 54) after Bonferroni correction for multiple testing; within these compounds, the phosphatidylcholine with the greatest decrease in abundance was PC ae C36:4 (delta = −0.34). Application of a 10% FDR revealed an additional 57 metabolites that were differentially abundant between groups. Pathway analysis suggests that the intervention results in changes in metabolites across many pathways such as phospholipid biosynthesis, choline metabolism, and lipoprotein metabolism. The observed plasma metabolomic alterations may reflect a Panchakarma-induced modulation of metabotypes. Panchakarma promoted statistically significant changes in plasma levels of phosphatidylcholines, sphingomyelins and others in just 6 days. Forthcoming studies that integrate metabolomics with genomic, microbiome and physiological parameters may facilitate a broader systems-level understanding and mechanistic insights into these integrative practices that are employed to promote health and well-being. |
| نوع الوثيقة: | Journal Article |
| اللغة: | English |
| تدمد: | 2045-2322 |
| Relation: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017211/pdf/; Scientific Reports |
| DOI: | 10.1038/srep32609 |
| URL الوصول: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:29407779 |
| حقوق: | open URL: http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA |
| رقم الأكسشن: | edshld.1.29407779 |
| قاعدة البيانات: | Digital Access to Scholarship at Harvard (DASH) |
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/srep32609 |