دورية أكاديمية
Similar synapse elimination motifs at successive relays in the same efferent pathway during development in mice
| العنوان: | Similar synapse elimination motifs at successive relays in the same efferent pathway during development in mice |
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| المؤلفون: | Sheu, Shu-Hsien, Tapia, Juan Carlos, Tsuriel, Shlomo, Lichtman, Jeff W |
| المصدر: | Sheu, Shu-Hsien, Juan Carlos Tapia, Shlomo Tsuriel, and Jeff W Lichtman. 2017. “Similar synapse elimination motifs at successive relays in the same efferent pathway during development in mice.” eLife 6 (1): e23193. doi:10.7554/eLife.23193. http://dx.doi.org/10.7554/eLife.23193. |
| بيانات النشر: | eLife Sciences Publications, Ltd, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | FAS Scholarly Articles |
| مصطلحات موضوعية: | synapse elimination, peripheral ganglia, synaptic competition, parasympathetic nerves, Mouse |
| الوصف: | In many parts of the nervous system, signals pass across multiple synaptic relays on their way to a destination, but little is known about how these relays form and the function they serve. To get some insight into this question we ask how the connectivity patterns are organized at two successive synaptic relays in a simple, cholinergic efferent pathway. We found that the organization at successive relays in the parasympathetic nervous system strongly resemble each other despite the different embryological origin and physiological properties of the pre- and postsynaptic cells. Additionally, we found a similar developmental synaptic pruning and elaboration strategy is used at both sites to generate their adult organizations. The striking parallels in adult innervation and developmental mechanisms at the relays argue that a general strategy is in operation. We discuss why from a functional standpoint this structural organization may amplify central signals while at the same time maintaining positional targeting. DOI: http://dx.doi.org/10.7554/eLife.23193.001 |
| نوع الوثيقة: | Journal Article |
| اللغة: | English |
| Relation: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315461/pdf/; eLife |
| DOI: | 10.7554/eLife.23193 |
| URL الوصول: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:31731861 |
| حقوق: | open URL: http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA |
| رقم الأكسشن: | edshld.1.31731861 |
| قاعدة البيانات: | Digital Access to Scholarship at Harvard (DASH) |
| DOI: | 10.7554/eLife.23193 |
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