دورية أكاديمية
Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes
| العنوان: | Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes |
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| المؤلفون: | Hockman, Dorit, Burns, Alan J, Schlosser, Gerhard, Gates, Keith P, Jevans, Benjamin, Mongera, Alessandro, Fisher, Shannon, Unlu, Gokhan, Knapik, Ela W, Kaufman, Charles K, Mosimann, Christian, Zon, Leonard I, Lancman, Joseph J, Dong, P Duc S, Lickert, Heiko, Tucker, Abigail S, Baker, Clare V H |
| المصدر: | Hockman, D., A. J. Burns, G. Schlosser, K. P. Gates, B. Jevans, A. Mongera, S. Fisher, et al. 2017. “Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes.” eLife 6 (1): e21231. doi:10.7554/eLife.21231. http://dx.doi.org/10.7554/eLife.21231. |
| بيانات النشر: | eLife Sciences Publications, Ltd, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | FAS Scholarly Articles HMS Scholarly Articles |
| مصطلحات موضوعية: | sea lamprey (Petromyzon marinus), neural crest, endoderm, neuroepithelial cells, carotid body, fate-mapping, Chicken, Mouse, Other, Zebrafish |
| الوصف: | The evolutionary origins of the hypoxia-sensitive cells that trigger amniote respiratory reflexes – carotid body glomus cells, and ‘pulmonary neuroendocrine cells’ (PNECs) - are obscure. Homology has been proposed between glomus cells, which are neural crest-derived, and the hypoxia-sensitive ‘neuroepithelial cells’ (NECs) of fish gills, whose embryonic origin is unknown. NECs have also been likened to PNECs, which differentiate in situ within lung airway epithelia. Using genetic lineage-tracing and neural crest-deficient mutants in zebrafish, and physical fate-mapping in frog and lamprey, we find that NECs are not neural crest-derived, but endoderm-derived, like PNECs, whose endodermal origin we confirm. We discover neural crest-derived catecholaminergic cells associated with zebrafish pharyngeal arch blood vessels, and propose a new model for amniote hypoxia-sensitive cell evolution: endoderm-derived NECs were retained as PNECs, while the carotid body evolved via the aggregation of neural crest-derived catecholaminergic (chromaffin) cells already associated with blood vessels in anamniote pharyngeal arches. DOI: http://dx.doi.org/10.7554/eLife.21231.001 |
| نوع الوثيقة: | Journal Article |
| اللغة: | English |
| Relation: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438250/pdf/; eLife |
| DOI: | 10.7554/eLife.21231 |
| URL الوصول: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:33029918 |
| حقوق: | open URL: http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA |
| رقم الأكسشن: | edshld.1.33029918 |
| قاعدة البيانات: | Digital Access to Scholarship at Harvard (DASH) |
| DOI: | 10.7554/eLife.21231 |
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